Department of Applied Chemistry, China Agricultural University, 2 Yuanmingyuan West Road, Beijing 100193, China.
Chemistry. 2012 Jul 23;18(30):9208-11. doi: 10.1002/chem.201200728. Epub 2012 Jun 19.
Asymmetric catalysis: A highly enantioselective and efficient procedure for the amino alcohol-zinc-catalyzed addition of 1,3-diynes to various aromatic, α,β-unsaturated, and aliphatic aldehydes has been developed. The present catalytic system was successfully applied in the concise synthesis of natural products such as (S)-strongylodiols A and B (see scheme).
开发了一种高效、高对映选择性的氨基酸醇-锌催化 1,3-二炔与各种芳香族、α,β-不饱和和脂肪族醛加成的方法。本催化体系成功应用于天然产物（S）-strongylodiols A 和 B 的简洁合成（见方案）。
