Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui 918-8503, Japan.
Ann Clin Biochem. 2012 Jul;49(Pt 4):387-90. doi: 10.1258/acb.2012.011139. Epub 2012 Jun 19.
We previously reported that the indicator of glycaemic control, glycated albumin (GA) levels, are low in relation to glycaemia in patients with high alanine aminotransferase (ALT) levels in non-alcoholic fatty liver disease because of chronic inflammation, and that the GA/glycated haemoglobin ratio (G/H ratio) is inversely correlated with hepatic function in patients with chronic liver disease. The severity of liver fibrosis is known to be a good indicator for surveillance, and for determining the prognosis and optimal treatment of non-alcoholic steatohepatitis (NASH). In this study, we aimed to investigate the clinical usefulness of measuring the G/H ratio for predicting the severity of liver fibrosis in patients with NASH.
The study subjects were 36 patients with histologically diagnosed NASH (19 men, 17 women; mean age 54.8±12.2 years, body mass index 28.3±5.0 kg/m2). The relationships of the G/H ratio to hepatic function tests and fibrosis stage in the liver were investigated.
The G/H ratio in patients with NASH was inversely correlated with ALT (P<0.001) and platelet count (P<0.0001). Furthermore, the G/H ratio was positively correlated with the fibrosis stage in liver (P=0.003).
These results suggest that the G/H ratio increases along with the fibrosis stage in patients with NASH.
我们之前报道过，在非酒精性脂肪性肝病患者中，由于慢性炎症，血糖控制指标糖化白蛋白（GA）水平与血糖水平相比较低，且 GA/糖化血红蛋白比值（G/H 比值）与慢性肝病患者的肝功能呈负相关。肝纤维化的严重程度是监测、判断非酒精性脂肪性肝炎（NASH）预后和选择最佳治疗方案的良好指标。在本研究中，我们旨在探讨测量 G/H 比值预测 NASH 患者肝纤维化严重程度的临床价值。
研究对象为 36 例经组织学诊断为 NASH 的患者（男 19 例，女 17 例；平均年龄 54.8±12.2 岁，体重指数 28.3±5.0kg/m2）。研究了 G/H 比值与肝功能检查和肝纤维化分期的关系。
NASH 患者的 G/H 比值与 ALT（P<0.001）和血小板计数（P<0.0001）呈负相关。此外，G/H 比值与肝纤维化分期呈正相关（P=0.003）。
这些结果表明，NASH 患者的 G/H 比值随纤维化分期的增加而升高。
