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糖化白蛋白与 HbA1c 的比值升高与乙型肝炎病毒感染患者的肝纤维化程度相关。

An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients.

机构信息

Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.

Department of Gastroenterology and Hepatology, Nissay Hospital, Itachibori 6-3-8, Nishi-ku, Osaka 550-0012, Japan.

出版信息

Gastroenterol Res Pract. 2014;2014:351396. doi: 10.1155/2014/351396. Epub 2014 Feb 17.

DOI:10.1155/2014/351396
PMID:24693282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3947677/
Abstract

Background. In hepatitis B virus- (HBV-) positive patients, the relationship between the metabolic variables and histological degree of liver fibrosis has been poorly investigated. Methods. A total of 176 HBV-positive patients were assessed in whom the ratios of glycated albumin-to-glycated hemoglobin (GA/HbA1c) were calculated in order to investigate the relationship with the degree of liver fibrosis. Results. The GA/HbA1c ratio increased in association with the severity of fibrosis (METAVIR scores: F0-1: 2.61 ± 0.24, F2: 2.65 ± 0.24, F3: 2.74 ± 0.38, and F4: 2.91 ± 0.63). The GA/HbA1c ratios were inversely correlated with four variables of liver function: the prothrombin time (PT) percentage (P < 0.0001), platelet count (P < 0.0001), albumin value (P < 0.0001), and cholinesterase value (P < 0.0001). The GA/HbA1c ratio was positively correlated with two well-known markers of liver fibrosis, FIB-4 (P < 0.0001) and the AST-to-platelet ratio index (APRI) (P < 0.0001). Furthermore, the GA/HbA1c showed better correlations with two variables of liver function (PT percentage and cholinesterase value) than did FIB-4 and with all four variables than did the APRI. Conclusion. The GA/HbA1c ratio is associated with the degree of liver fibrosis in HBV-positive patients.

摘要

背景

在乙型肝炎病毒（HBV）阳性患者中，代谢变量与肝纤维化组织学程度之间的关系尚未得到充分研究。

方法

评估了 176 名 HBV 阳性患者，计算糖化白蛋白与糖化血红蛋白（GA/HbA1c）的比值，以研究其与肝纤维化程度的关系。

结果

GA/HbA1c 比值随着纤维化程度的加重而增加（METAVIR 评分：F0-1：2.61±0.24、F2：2.65±0.24、F3：2.74±0.38、F4：2.91±0.63）。GA/HbA1c 比值与肝功能的四个变量呈负相关：凝血酶原时间（PT）百分比（P<0.0001）、血小板计数（P<0.0001）、白蛋白值（P<0.0001）和胆碱酯酶值（P<0.0001）。GA/HbA1c 比值与两种公认的肝纤维化标志物 FIB-4（P<0.0001）和天冬氨酸氨基转移酶与血小板比值指数（APRI）（P<0.0001）呈正相关。此外，GA/HbA1c 与两个肝功能变量（PT 百分比和胆碱酯酶值）的相关性优于 FIB-4，与所有四个变量的相关性优于 APRI。

结论

GA/HbA1c 比值与 HBV 阳性患者的肝纤维化程度相关。

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本文引用的文献

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Predicting portal hypertension and variceal bleeding using non-invasive measurements of metabolic variables.利用代谢变量的无创测量预测门静脉高压和静脉曲张出血。
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Association of amino acid imbalance with the severity of liver fibrosis and esophageal varices.
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4
Corrigendum to "An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients".《糖化白蛋白与糖化血红蛋白比值升高与乙肝病毒阳性患者肝纤维化程度相关》勘误
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