Zheng Hui, Law Ping-Yee, Loh Horace H
Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences Guangzhou, China.
Front Genet. 2012 Jun 15;3:113. doi: 10.3389/fgene.2012.00113. eCollection 2012.
Non-coding RNAs (ncRNAs), especially microRNAs, are reported to be involved in a variety of biological processes, including several processes related to drug addiction. It has been suggested that the biological functions of opioids, one typical type of addictive drugs, are regulated by ncRNAs. In the current review, we examine a variety of mechanisms through which ncRNAs could regulate μ-opioid receptor (OPRM1) activities and thereby contribute to the development of opioid addiction. Using miR-23b as an example, we present the possible ways in which ncRNA-mediated regulation of OPRM1 expression could impact opioid addiction. Using miR-190 as an example, we demonstrate the critical roles played by ncRNAs in the signal cascade from receptor to systemic responses, including the possible modulation of adult neurogenesis and in vivo contextual memory. After discussing the possible targets of ncRNAs involved in the development of opioid addiction, we summarize the mechanisms underlying the interaction between ncRNAs and opioid addiction and present suggestions for further study.
据报道，非编码RNA（ncRNA），尤其是微小RNA，参与多种生物学过程，包括与药物成瘾相关的多个过程。有人提出，阿片类药物（一种典型的成瘾药物）的生物学功能受ncRNA调控。在本综述中，我们研究了ncRNA调节μ-阿片受体（OPRM1）活性并由此导致阿片类药物成瘾的多种机制。以miR-23b为例，我们介绍了ncRNA介导的OPRM1表达调节可能影响阿片类药物成瘾的方式。以miR-190为例，我们证明了ncRNA在从受体到全身反应的信号级联反应中所起的关键作用，包括对成体神经发生和体内情境记忆的可能调节。在讨论了参与阿片类药物成瘾发展的ncRNA的可能靶点后，我们总结了ncRNA与阿片类药物成瘾之间相互作用的潜在机制，并提出了进一步研究的建议。
