Zor'kina T A
Vopr Med Khim. 1979 Sep-Oct;25(5):534-7.
An increase in activity of several dehydrogenases of tricarboxylic acid cycle (NADP-dependent malate dehydrogenase, alpha-ketoglutarate dehydrogenase) was observed in rat liver tissue under conditions of acute hemorrhage. The enzymatic activity was slightly higher in the group of animals with relatively prolonged life-time as compared with those, which lived less than 4 hrs. Activity of cytochrome oxidase was inhilited in the both groups of animals (by 27% and 29%, respectively). The less distinct decrease in both temperature in the group of animals with prolonged life-time might maintain the rate of Krebs cycle substrates oxidation. Activation of respiration in liver tissue under conditions of the hemorrhage is considered as a compensatory reaction tending to improve oxygen utilization in hypoxia. At the same time, inhibition oy cytochrome oxidase demonstrates the impairment of electron transport and decreased rate of energy production in liver mitochondria.
在急性出血情况下，观察到大鼠肝脏组织中三羧酸循环的几种脱氢酶（NADP依赖的苹果酸脱氢酶、α-酮戊二酸脱氢酶）活性增加。与存活时间少于4小时的动物组相比，存活时间相对较长的动物组的酶活性略高。两组动物的细胞色素氧化酶活性均受到抑制（分别降低27%和29%）。存活时间较长的动物组体温下降不太明显，这可能维持了三羧酸循环底物的氧化速率。出血情况下肝脏组织呼吸的激活被认为是一种代偿反应，倾向于改善缺氧时的氧利用。同时，细胞色素氧化酶的抑制表明肝脏线粒体中电子传递受损，能量产生速率降低。
