Deev A I, Biketova D Kh, Spirichev V B, Blazheevich N V
Vopr Med Khim. 1979 Sep-Oct;25(5):617-22.
Hemolytic effects of the vitamins of the D group (ergocalciferol - D2, cholecalciferol - D3, and 1 alpha-hydroxycholecalciferol - 1 alpha-OH-D3) were compared using rat erythrocytes. The latent period of hemolysis, caused by 1 alpha-OH-D3 was approximately 3-fold shorter as compared with the hemolysis caused by D2 or D3. Apparent values for energy of activation of hemolysis, estimated at 30-45 degrees, constituted for D2 - 23.2 kcal/mol, D3 - 25.3 kcal/mol, 1 alpha-OH-D3 - 13.1 kcal/mol. Despite the higher hemolytic activity, the rate of 1 alpha-ON-D3 autooxidation was distinctly lower than that of D3.
使用大鼠红细胞比较了维生素D组（麦角钙化醇 - D2、胆钙化醇 - D3和1α-羟基胆钙化醇 - 1α-OH-D3）的溶血作用。与D2或D3引起的溶血相比，1α-OH-D3引起的溶血潜伏期缩短了约3倍。在30 - 45摄氏度下估计的溶血活化能表观值，D2为23.2千卡/摩尔，D3为25.3千卡/摩尔，1α-OH-D3为13.1千卡/摩尔。尽管1α-ON-D3的溶血活性较高，但其自动氧化速率明显低于D3。
