Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Am J Hypertens. 2012 Oct;25(10):1124-30. doi: 10.1038/ajh.2012.88. Epub 2012 Jun 21.
Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension.
We first examined serum FABP4 concentrations in 18 normotensives (NT) and 30 nontreated essential hypertensives (EHT). The EHT were divided into 18 insulin-sensitive EHT (EHT-S) and 12 insulin-resistant EHT (EHT-R) based on their insulin-sensitivity index, the M value, determined by the hyperinsulinemic-euglycemic clamp technique. In the second study, we determined FABP4 levels in 30 young NT men with or without a family history of hypertension (FH(+) and FH(-), respectively; n = 15 each).
Serum FABP4 level was significantly higher in the EHT-R than in the NT, whereas elevation of FABP4 level in the EHT-S was not statistically significant. FABP4 level was positively correlated with age, body mass index (BMI), blood pressure, and triglycerides and negatively correlated with the M value. FABP4 level was an independent predictor of mean arterial pressure after adjustment of age, gender, and adiposity. The FH(+) group had a significantly lower level of M value and higher level of FABP4 than did the FH(-) group, and FABP4 concentration was an independent determinant of the M value.
FABP4 contributes to blood pressure elevation and atherogenic metabolic phenotype in hypertensives, and the elevation of FABP4 is predisposed by a family history of hypertension.
脂肪酸结合蛋白 4（FABP4/A-FABP/aP2）是一种脂质伴侣蛋白，在脂肪细胞和巨噬细胞中均有表达。最近的研究表明，脂肪细胞分泌 FABP4，血清 FABP4 水平升高与肥胖、胰岛素抵抗和动脉粥样硬化有关。然而，关于 FABP4 在原发性高血压中的作用知之甚少。
我们首先检测了 18 名正常血压者（NT）和 30 名未经治疗的原发性高血压患者（EHT）的血清 FABP4 浓度。根据胰岛素敏感指数 M 值，将 EHT 分为 18 名胰岛素敏感 EHT（EHT-S）和 12 名胰岛素抵抗 EHT（EHT-R）。在第二项研究中，我们检测了 30 名年轻 NT 男性的 FABP4 水平，这些男性中分别有（FH(+)）和无（FH(-)）家族高血压史，每组 15 人。
EHT-R 组血清 FABP4 水平明显高于 NT 组，而 EHT-S 组 FABP4 水平升高无统计学意义。FABP4 水平与年龄、体重指数（BMI）、血压和甘油三酯呈正相关，与 M 值呈负相关。调整年龄、性别和肥胖后，FABP4 水平是平均动脉压的独立预测因子。FH(+)组的 M 值明显低于 FH(-)组，FABP4 水平也明显高于 FH(-)组，且 FABP4 浓度是 M 值的独立决定因素。
FABP4 导致高血压患者血压升高和动脉粥样硬化代谢表型，家族高血压史使 FABP4 升高的倾向性增加。
