Research Unit on Lipids and Atherosclerosis, Universitat Rovira i Virgili, Internal Medicine Department, Sant Joan University Hospital, IISPV, CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Reus, Spain.
Atherosclerosis. 2010 Nov;213(1):329-31. doi: 10.1016/j.atherosclerosis.2010.07.026. Epub 2010 Jul 27.
Adipocyte fatty acid-binding protein (FABP4) plasma levels are higher in type 2 diabetes (T2D). Endothelial dysfunction is also common in T2D. We have investigated the relationship between circulating FABP4 levels and endothelial function in diabetic patients.
In 257 patients (105 diabetic and 152 non-diabetic) at increased risk of cardiovascular disease, we measured circulating FABP4, reactive hyperemia index (RHI) by peripheral artery tonometry, intima-media thickness, and biomarkers of inflammation, oxidation and endothelial function.
In T2D subjects, FABP4 was negatively associated with endothelial function, as measured by RHI (r=-0.226, P=0.05). In a stepwise multivariate linear regression model, FABP4 was a predictor of RHI in T2D patients (P=0.04).
Circulating levels of FABP4 are inversely associated with endothelial function in T2D patients, as measured by RHI. We suggest a direct effect of plasma FABP4 on the vascular endothelium in those with T2D.
脂肪细胞脂肪酸结合蛋白（FABP4）在 2 型糖尿病（T2D）患者中的血浆水平较高。内皮功能障碍在 T2D 中也很常见。我们研究了循环 FABP4 水平与糖尿病患者内皮功能之间的关系。
在 257 名患有心血管疾病风险增加的患者（105 名糖尿病患者和 152 名非糖尿病患者）中，我们通过外周动脉张力测定法测量了循环 FABP4、反应性充血指数（RHI）、内膜-中层厚度以及炎症、氧化和内皮功能的生物标志物。
在 T2D 患者中，FABP4 与内皮功能呈负相关，表现为 RHI（r=-0.226，P=0.05）。在逐步多元线性回归模型中，FABP4 是 T2D 患者 RHI 的预测因子（P=0.04）。
循环 FABP4 水平与 T2D 患者的内皮功能呈负相关，通过 RHI 进行测量。我们建议在 T2D 患者中，血浆 FABP4 对血管内皮具有直接作用。
