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带状疱疹后三叉神经痛经辣椒素 8% 透皮贴剂治疗有效:病例报告。

Trigeminal postherpetic neuralgia responsive to treatment with capsaicin 8 % topical patch: a case report.

机构信息

Department of Pain Medicine and Palliative Care, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY, USA.

出版信息

J Headache Pain. 2012 Oct;13(7):587-9. doi: 10.1007/s10194-012-0467-0. Epub 2012 Jun 21.

Abstract

Postherpetic neuralgia has been variably defined but is generally understood to be pain that persists for longer than a few months after an attack of herpes zoster. Pain persists for years in approximately 10 % of those afflicted with acute herpes zoster. The likelihood of postherpetic neuralgia increases with older age, severity of the zoster, trigeminal location, and other factors. Postherpetic neuralgia is a neuropathic pain and treatment usually involves sequential trials of topical and systemic drugs; a variety of other therapies may be considered in refractory cases. A new topical capsaicin 8 % patch has been approved for this indication based on the positive studies in patients with non-trigeminal postherpetic neuralgia. Experience with the use of the capsaicin 8 % patch for trigeminal distribution neuralgia is lacking. We report a case of trigeminal postherpetic neuralgia which was safely and effectively treated with capsaicin 8 % patch.

摘要

带状疱疹后神经痛的定义存在差异,但通常被理解为带状疱疹发作后持续数月以上的疼痛。约 10%的急性带状疱疹患者的疼痛会持续数年。带状疱疹后神经痛的发生概率随年龄增长、带状疱疹的严重程度、三叉神经位置等因素而增加。带状疱疹后神经痛是一种神经病理性疼痛,治疗通常涉及外用和系统药物的序贯试验;在难治性病例中,可以考虑多种其他治疗方法。一项新的外用 8%辣椒素贴片已被批准用于该适应证,其依据是对非三叉神经带状疱疹后神经痛患者的阳性研究。缺乏使用 8%辣椒素贴片治疗三叉神经分布区神经痛的经验。我们报告了 1 例三叉神经带状疱疹后神经痛,使用 8%辣椒素贴片安全有效地进行了治疗。

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本文引用的文献

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Topical capsaicin. The fire of a 'hot' medicine is reignited.局部辣椒素。“热”药之火重燃。
Expert Opin Pharmacother. 2010 Jun;11(8):1359-71. doi: 10.1517/14656566.2010.481670.
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An update on the treatment of postherpetic neuralgia.带状疱疹后神经痛治疗的最新进展。
J Pain. 2008 Jan;9(1 Suppl 1):S19-30. doi: 10.1016/j.jpain.2007.10.006.

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