Petran Elena Madalina, Periferakis Argyrios, Troumpata Lamprini, Periferakis Aristodemos-Theodoros, Scheau Andreea-Elena, Badarau Ioana Anca, Periferakis Konstantinos, Caruntu Ana, Savulescu-Fiedler Ilinca, Sima Romina-Marina, Calina Daniela, Constantin Carolina, Neagu Monica, Caruntu Constantin, Scheau Cristian
Department of Biochemistry, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Toxicology, Grigore Alexandrescu Emergency Children's Hospital, 011743 Bucharest, Romania.
Curr Issues Mol Biol. 2024 Jul 24;46(8):7895-7943. doi: 10.3390/cimb46080468.
Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications. Capsaicin is known to act through the TRPV1 receptor, which exists in various tissues; capsaicin is hepatically metabolised, having a half-life correlated with the method of application. Research on various applications of capsaicin in different formulations is still ongoing. Thus, local capsaicin applications have a pronounced anti-inflammatory effect, while systemic applications have a multitude of different effects because their increased lipophilic character ensures their augmented bioavailability. Furthermore, various teams have documented capsaicin's anti-cancer effects, proven both in vivo and in vitro designs. A notable constraint in the therapeutic effects of capsaicin is its increased toxicity, especially in sensitive tissues. Regarding the traditional applications of capsaicin, apart from all the effects recorded as medicinal effects, the application of capsaicin in acupuncture points has been demonstrated to be effective and the combination of acupuncture and capsaicin warrants further research. Finally, capsaicin has demonstrated antimicrobial effects, which can supplement its anti-inflammatory and anti-carcinogenic actions.
辣椒素是辣椒中最主要的辛辣化合物，几个世纪以来一直被用于传统医学体系；它已经有了许多既定的临床和工业应用。已知辣椒素通过存在于各种组织中的TRPV1受体发挥作用；辣椒素在肝脏中代谢，其半衰期与应用方法相关。关于辣椒素在不同制剂中的各种应用的研究仍在进行中。因此，局部应用辣椒素有显著的抗炎作用，而全身应用则有多种不同的作用，因为其亲脂性增加确保了其生物利用度提高。此外，多个团队已经记录了辣椒素的抗癌作用，在体内和体外实验设计中均得到证实。辣椒素治疗效果的一个显著限制是其毒性增加，尤其是在敏感组织中。关于辣椒素的传统应用，除了记录为药用效果的所有作用外，辣椒素在穴位的应用已被证明是有效的，针灸与辣椒素的联合应用值得进一步研究。最后，辣椒素已显示出抗菌作用，这可以补充其抗炎和抗癌作用。
