Department of Medical Chemistry, Semmelweis University, Budapest 1444, Hungary.
Bioinformatics. 2012 Aug 15;28(16):2202-4. doi: 10.1093/bioinformatics/bts352. Epub 2012 Jun 19.
The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer represent modules of the lower layer. The tool assigns module cores, which predict the function of the whole module, and determines key nodes bridging two or multiple modules. The plug-in has a detailed JAVA-based graphical interface with various colouring options. The ModuLand tool can run on Windows, Linux or Mac OS. We demonstrate its use on protein structure and metabolic networks.
The plug-in and its user guide can be downloaded freely from: http://www.linkgroup.hu/modules.php.
ModuLand 插件为 Cytoscape 用户提供了一种算法，用于确定广泛重叠的网络模块。此外，它还可以识别几个层次结构的模块，其中较高层次结构的元节点表示较低层次结构的模块。该工具分配模块核心，这些核心预测整个模块的功能，并确定连接两个或多个模块的关键节点。该插件具有一个详细的基于 JAVA 的图形界面，具有各种着色选项。ModuLand 工具可以在 Windows、Linux 或 Mac OS 上运行。我们在蛋白质结构和代谢网络上展示了它的用法。
插件及其用户指南可从以下网址免费下载：http://www.linkgroup.hu/modules.php。
