• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2,6-二氯-7-异丙基-7H-嘌呤

2,6-Dichloro-7-isopropyl-7H-purine.

作者信息

Hloušková Nikola, Rouchal Michal, Nečas Marek, Vícha Robert

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1585. doi: 10.1107/S160053681201879X. Epub 2012 May 2.

DOI:10.1107/S160053681201879X
PMID:22719396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3379198/
Abstract

In the title mol-ecule, C(8)H(8)Cl(2)N(4), the essentially planar imidazole and pyrimidine rings [maximum deviations of 0.0030 (15) and 0.0111 (15) Å, respectively] make a dihedral angle of 1.32 (8)°. In the crystal, the fused-ring systems are stacked approximately parallel to the bc plane, with a centroid-centroid distance between inversion-related pyrimidine rings of 3.5189 (9) Å.

摘要

在标题分子C₈H₈Cl₂N₄中，基本呈平面状的咪唑环和嘧啶环[最大偏差分别为0.0030 (15) Å和0.0111 (15) Å]形成的二面角为1.32 (8)°。在晶体中，稠环体系大致平行于bc平面堆叠，反演相关嘧啶环之间的质心间距为3.5189 (9) Å。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e178/3379198/1912239dc459/e-68-o1585-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e178/3379198/0a892b9613f2/e-68-o1585-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e178/3379198/1912239dc459/e-68-o1585-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e178/3379198/0a892b9613f2/e-68-o1585-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e178/3379198/1912239dc459/e-68-o1585-fig2.jpg

相似文献

1
2,6-Dichloro-7-isopropyl-7H-purine.2,6-二氯-7-异丙基-7H-嘌呤
Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1585. doi: 10.1107/S160053681201879X. Epub 2012 May 2.
2
4,4-Dichloro-tricyclo-[5.4.0.0]undeca-7,9,11-triene.4,4-二氯-三环-[5.4.0.0]十一碳-7,9,11-三烯
Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 21;64(Pt 7):o1310. doi: 10.1107/S160053680801831X.
3
2-(1H-Imidazol-1-yl)-3-isopropyl-1-benzothieno[3,2-d]pyrimidin-4(3H)-one.2-（1H-咪唑-1-基）-3-异丙基-1-苯并噻吩并[3,2-d]嘧啶-4（3H）-酮
Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 6;64(Pt 1):o222. doi: 10.1107/S1600536807064598.
4
Benzene-1,4-diol-5-(1H-imidazol-1-yl)pyrimidine (1/1).苯-1,4-二醇-5-(1H-咪唑-1-基)嘧啶(1/1)
Acta Crystallogr Sect E Struct Rep Online. 2011 Nov;67(Pt 11):o3073. doi: 10.1107/S1600536811043819. Epub 2011 Oct 29.
5
Ethyl 2-(4-meth-oxy-phen-yl)-1-[3-(2-oxopyrrolidin-1-yl)prop-yl]-1H-benzimidazole-5-carboxyl-ate.2-(4-甲氧基苯基)-1-[3-(2-氧代吡咯烷-1-基)丙基]-1H-苯并咪唑-5-羧酸乙酯
Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o308-9. doi: 10.1107/S1600536811055966. Epub 2012 Jan 7.
6
9-(1,1-Dimethyl-3-oxobut-yl)adenine.9-(1,1-二甲基-3-氧代丁基)腺嘌呤
Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 4;66(Pt 10):o2475. doi: 10.1107/S1600536810034628.
7
1-[2-(2,4-Dichloro-benz-yloxy)-2-(furan-2-yl)eth-yl]-1H-benzotriazole.1-[2-(2,4-二氯苄氧基)-2-(呋喃-2-基)乙基]-1H-苯并三唑
Acta Crystallogr Sect E Struct Rep Online. 2012 Jan;68(Pt 1):o139-40. doi: 10.1107/S1600536811053104. Epub 2011 Dec 17.
8
1,2-Bis[2-(2-nitro-1H-imidazol-1-yl)eth-oxy]ethane.1,2-双[2-(2-硝基-1H-咪唑-1-基)乙氧基]乙烷
Acta Crystallogr Sect E Struct Rep Online. 2008 Aug 6;64(Pt 9):o1690. doi: 10.1107/S1600536808023726.
9
1-(3,3-Dichloro-all-yloxy)-4-methyl-2-nitro-benzene.1-（3,3-二氯烯丙氧基）-4-甲基-2-硝基苯
Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1929. doi: 10.1107/S1600536812023057. Epub 2012 May 31.
10
7-(4-Methoxy-phen-yl)-5-methyl-9-phenyl-7H-pyrrolo[2',3':4,5]pyrimido[1,6-d]tetrazole.7-（4-甲氧基-苯基）-5-甲基-9-苯基-7H-吡咯并[2'，3'：4,5]嘧啶并[1,6-d]四唑
Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 19;66(Pt 1):o212-3. doi: 10.1107/S1600536809053653.

引用本文的文献

1
Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity.金刚烷取代嘌呤及其 β-环糊精包合物的合成与生物活性。
Int J Mol Sci. 2021 Nov 24;22(23):12675. doi: 10.3390/ijms222312675.

本文引用的文献

1
(1-Adamant-yl){4-[(2-chloro-9-isopropyl-9H-purin-6-yl)aminometh-yl]phen-yl}methanone trichloro-methane solvate.（1-金刚烷基）{4-[(2-氯-9-异丙基-9H-嘌呤-6-基)氨基甲基]苯基}甲酮三氯甲烷溶剂合物
Acta Crystallogr Sect E Struct Rep Online. 2009 May 14;65(Pt 6):o1268. doi: 10.1107/S1600536809016596.
2
2-(1-Adamant-yl)-1-{4-[(2-chloro-9-isopropyl-9H-purin-6-yl)amino-meth-yl]phen-yl}ethanone.2-（1-金刚烷基）-1-{4-[(2-氯-9-异丙基-9H-嘌呤-6-基)氨基甲基]苯基}乙酮
Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 14;65(Pt 2):o298-9. doi: 10.1107/S160053680900052X.
3
2-Chloro-9-isopropyl-N,N-dimethyl-9H-purin-6-amine.
2-氯-9-异丙基-N,N-二甲基-9H-嘌呤-6-胺
Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 2;66(Pt 5):o1016. doi: 10.1107/S1600536810011797.
4
Selective synthesis of 7-substituted purines via 7,8-dihydropurines.通过 7,8-二氢嘌呤选择性合成 7-取代嘌呤。
Org Lett. 2010 Dec 17;12(24):5724-7. doi: 10.1021/ol1025525. Epub 2010 Nov 19.
5
Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.来源于罗斯考维汀的细胞周期蛋白依赖性激酶和酪蛋白激酶1的双特异性抑制剂。
J Med Chem. 2008 Sep 11;51(17):5229-42. doi: 10.1021/jm800109e. Epub 2008 Aug 13.
6
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
7
The purines: potent and versatile small molecule inhibitors and modulators of key biological targets.嘌呤：关键生物靶点的强效且多功能小分子抑制剂和调节剂。
Bioorg Med Chem. 2006 Jun 15;14(12):3987-4006. doi: 10.1016/j.bmc.2005.12.060. Epub 2006 Feb 24.