Singh V B, Onaivi E S, Phan T H, Boadle-Biber M C
Department of Physiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond 23298.
Brain Res. 1990 Oct 15;530(1):49-53. doi: 10.1016/0006-8993(90)90656-v.
Sound stress (SS) (120-dB pulses of 100 ms duration, every min for 1 h) produces an elevation of in vitro cortical or midbrain tryptophan hydroxylase activity from male Sprague-Dawley rats that is abolished, in vitro, by incubation of the enzyme preparation with alkaline phosphatase. SS, when repeated on 3 different occasions, the first 2 sessions 24 h apart and the 2nd and 3rd session separated by 48 h, produces a stable increase in the in vitro enzyme activity that is unaffected by alkaline phosphatase. Bilateral lesions to the central nucleus of the amygdala block both increases in enzyme activity obtained in response to acute and repeated SS, but leave enzyme activity from sham-stressed rats unaffected.
声音应激（SS）（持续100毫秒、120分贝的脉冲，每分钟一次，共1小时）可使雄性斯普拉格-道利大鼠体外皮质或中脑色氨酸羟化酶活性升高，而在体外将酶制剂与碱性磷酸酶孵育后，这种升高作用会被消除。当在3个不同时间重复施加SS时，前两次间隔24小时，第二次和第三次间隔48小时，会使体外酶活性稳定增加，且不受碱性磷酸酶影响。双侧杏仁核中央核损伤会阻断急性和重复SS所引起的酶活性增加，但对假应激大鼠的酶活性没有影响。
