阿尔茨海默病早期的认知和神经精神症状差异：库奥皮奥ALSOVA研究
Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer's Disease: Kuopio ALSOVA Study.
作者信息
Hallikainen Ilona, Koivisto Anne M, Paajanen Teemu, Hiltunen Asta, Karppi Pertti, Vanhanen Matti, Välimäki Tarja, Herukka Sanna-Kaisa, Soininen Hilkka, Hänninen Tuomo
机构信息
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Mikkeli, Finland.
出版信息
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):209-18. doi: 10.1159/000338231. Epub 2012 May 5.
BACKGROUND/AIM: Alzheimer's disease (AD) causes impairment in memory and other cognitive functions as well as neuropsychiatric symptoms and limitations in the activities of daily living (ADL). The aim of this study was to examine whether demographic variables, dementia severity, ADL and neuropsychiatric symptoms are associated with cognition in very mild or mild AD.
METHODS
We analyzed the baseline data of 236 patients with very mild or mild AD participating in a prospective AD follow-up study (ALSOVA). The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery total score was used in the evaluation of the global cognitive performance.
RESULTS
Cognition was associated with dementia severity and ADL but not with neuropsychiatric symptoms. ADL functions were associated with both cognitive performance and neuropsychiatric symptoms.
CONCLUSION
Even patients with very mild or mild AD may exhibit neuropsychiatric symptoms not related to cognitive impairment. The results of this study emphasize the importance of taking a multidimensional approach to the diagnostic and prognostic evaluation of AD patients already in the early stages of the disease.
背景/目的：阿尔茨海默病（AD）会导致记忆及其他认知功能受损，以及神经精神症状和日常生活活动（ADL）受限。本研究的目的是检验人口统计学变量、痴呆严重程度、ADL和神经精神症状是否与极轻度或轻度AD患者的认知相关。
方法
我们分析了参与一项前瞻性AD随访研究（ALSOVA）的236例极轻度或轻度AD患者的基线数据。采用阿尔茨海默病神经心理成套测验总分评估整体认知表现。
结果
认知与痴呆严重程度和ADL相关，但与神经精神症状无关。ADL功能与认知表现和神经精神症状均相关。
结论
即使是极轻度或轻度AD患者也可能出现与认知障碍无关的神经精神症状。本研究结果强调了在疾病早期阶段对AD患者进行诊断和预后评估时采用多维度方法的重要性。
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