Department of Education and Psychology, University of Eastern Finland, Joensuu, Finland.
Institute of Clinical Medicine, Neurology, School of Medicine, University of Eastern Finland, Kuopio, Finland.
J Alzheimers Dis. 2018;64(1):269-279. doi: 10.3233/JAD-171059.
Impaired cognition and activities of daily living (ADL) are core symptoms of Alzheimer's disease (AD), but their relationship is unclear.
To explore relationships between cognitive domains and functional ability during 5-year follow-up in persons with AD.
We analyzed ALSOVA study data from 236 individuals with very mild or mild AD at baseline. The CERAD Neuropsychological Battery (CERAD-NB) was used as a cognitive measure and Alzheimer's Disease Cooperative Study ADL (ADCS-ADL) as a functional measure, analyzing the IADL and BADL sub-scores separately. Annual regression models and linear mixed-effect models (LMMs) covering a 5-year follow-up period were used.
Annually, the CERAD-NB total and especially Verbal Fluency, Clock Drawing, and Constructional Praxis were associated with the total ADCS-ADL and IADL scores increasingly yet modestly, and to a lesser extent the BADL score. In the LMMs, the same measures and MMSE were associated with ADL.
Measures of executive function and visuoconstructive skills appear to be associated with caregiver-interview based ADL measure during the progression of AD.
认知障碍和日常生活活动能力（ADL）是阿尔茨海默病（AD）的核心症状，但它们之间的关系尚不清楚。
在 AD 患者的 5 年随访中，探讨认知领域与功能能力之间的关系。
我们分析了基线时有非常轻度或轻度 AD 的 236 名个体的 ALSOVA 研究数据。使用 CERAD 神经心理学电池（CERAD-NB）作为认知测量，Alzheimer's Disease Cooperative Study ADL（ADCS-ADL）作为功能测量，分别分析 IADL 和 BADL 子评分。使用涵盖 5 年随访期的年度回归模型和线性混合效应模型（LMM）。
每年，CERAD-NB 总分，特别是词语流畅性、时钟绘图和结构实践，与 ADCS-ADL 和 IADL 总分以及 BADL 分数呈逐渐增加但适度的相关性，与 ADL 的相关性较小。在 LMM 中，同样的措施和 MMSE 与 ADL 相关。
执行功能和视觉建构技能的测量似乎与 AD 进展过程中基于护理者访谈的 ADL 测量相关。
