男性衰老过程中的部分雄激素缺乏、抑郁与睾酮补充治疗
Partial androgen deficiency, depression, and testosterone supplementation in aging men.
机构信息
Department of Neurosciences, Institute of Psychiatry, University of Parma, Piazza Matteotti 9, 43100 Parma, Italy.
出版信息
Int J Endocrinol. 2012;2012:280724. doi: 10.1155/2012/280724. Epub 2012 Jun 7.
Abstract
The aim of this review was to summarize current knowledge on the correlation between depressive symptoms with a syndrome called partial androgen deficiency of the aging male (PADAM) and on the potential benefits of testosterone (T) treatment on mood. Despite, the causative nature of the relationship between low T levels and depression is uncertain, many hypogonadal men suffer from depression and vice versa several depressed patients are affected by hypogonadism. Supplementation with testosterone failed to show sound evidence of effectiveness in the treatment of depression. Nevertheless, testosterone supplementation has proved to be effective on some domains significant for the quality of life of aged patients with PADAM (sexual function and cognitive functions, muscular strengths).
摘要
本次综述旨在总结目前关于抑郁症状与男性迟发性性腺功能减退症（PADAM）综合征之间相关性的认识，以及睾酮（T）治疗对情绪的潜在益处。尽管低 T 水平与抑郁之间的因果关系尚不确定，但许多性腺功能减退症男性患有抑郁症，反之亦然，许多抑郁症患者患有性腺功能减退症。补充睾酮在治疗抑郁症方面没有确凿的证据证明其有效性。然而，睾酮补充剂已被证明对改善 PADAM 老年患者的生活质量（性功能和认知功能、肌肉力量）有一些重要领域有效果。
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