急性髓系白血病中的肿瘤免疫逃逸：由于抗原呈递不足导致 II 类相关不变链肽的表达。
Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation.
机构信息
Department of Hematology; Cancer Center Amsterdam; VU Institute for Cancer and Immunology; VU University Medical Center; Amsterdam, The Netherlands ; Department of Immunopathology; Sanquin Research and Landsteiner Laboratory; Academic Medical Center; University of Amsterdam; Amsterdam, The Netherlands.
出版信息
Oncoimmunology. 2012 Mar 1;1(2):211-213. doi: 10.4161/onci.1.2.18100.
In this overview, we discuss the role of class II-associated invariant chain peptide (CLIP) in acute myeloid leukemia (AML), one of the few tumors expressing HLA class II. The clinical impact, function and regulation of CLIP expression on leukemic cells is addressed, indicating its potential as immunotherapeutic target in AML.
在本篇综述中，我们讨论了 II 类相关不变链肽（CLIP）在急性髓系白血病（AML）中的作用，AML 是少数表达 HLA Ⅱ类的肿瘤之一。本文讨论了 CLIP 在白血病细胞中的表达的临床意义、功能和调控，表明其在 AML 中作为免疫治疗靶点的潜力。
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