抗 CD73 癌症疗法的双刃剑效应。
The double-edge sword effect of anti-CD73 cancer therapy.
机构信息
Centre de Recherche du Centre Hospitalier de l'Université de Montréa; Faculté de Pharmacie et Institut du Cancer de Montréal; Montréal, Québec, Canada.
出版信息
Oncoimmunology. 2012 Mar 1;1(2):217-218. doi: 10.4161/onci.1.2.18101.
Abstract
We and others have identified CD73 as a new cancer target. I hereafter discuss that targeted blockade of CD73 has the effect of a "double-edge sword," able on the one hand to rescue endogenous adaptive anti-tumor immune responses, and on the other hand, inhibit the metastatic potential of tumor cells.
摘要
我们和其他人已经确定 CD73 是一个新的癌症靶点。在此，我将讨论靶向阻断 CD73 具有“双刃剑”的效果，一方面能够挽救内源性适应性抗肿瘤免疫反应，另一方面能够抑制肿瘤细胞的转移潜力。
相似文献
1
The double-edge sword effect of anti-CD73 cancer therapy.抗 CD73 癌症疗法的双刃剑效应。
Oncoimmunology. 2012 Mar 1;1(2):217-218. doi: 10.4161/onci.1.2.18101.
2
Anti-CD73 therapy impairs tumor angiogenesis.抗 CD73 治疗可损害肿瘤血管生成。
Int J Cancer. 2014 Mar 15;134(6):1466-73. doi: 10.1002/ijc.28456. Epub 2013 Sep 18.
3
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis.抗 CD73 抗体治疗抑制乳腺癌生长和转移。
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1547-52. doi: 10.1073/pnas.0908801107. Epub 2010 Jan 4.
4
Downregulation of CD73 associates with T cell exhaustion in AML patients.CD73 的下调与 AML 患者 T 细胞耗竭有关。
J Hematol Oncol. 2019 Apr 24;12(1):40. doi: 10.1186/s13045-019-0728-3.
5
CD73 as a potential opportunity for cancer immunotherapy.CD73 作为癌症免疫治疗的潜在机会。
Expert Opin Ther Targets. 2019 Feb;23(2):127-142. doi: 10.1080/14728222.2019.1559829. Epub 2018 Dec 26.
6
CD73-adenosine: a next-generation target in immuno-oncology.CD73-腺苷：免疫肿瘤学的新一代靶点
Immunotherapy. 2016 Feb;8(2):145-63. doi: 10.2217/imt.15.106. Epub 2016 Jan 25.
7
CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model.CD73 阻断增强了小鼠直肠癌模型中的局部和远隔放疗效应。
BMC Cancer. 2020 May 12;20(1):411. doi: 10.1186/s12885-020-06893-3.
8
Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs.靶向 CD73 增强了抗 PD-1 和抗 CTLA-4 mAbs 的抗肿瘤活性。
Clin Cancer Res. 2013 Oct 15;19(20):5626-35. doi: 10.1158/1078-0432.CCR-13-0545. Epub 2013 Aug 27.
9
Targeting the Immunomodulatory CD73/Adenosine System to Improve the Therapeutic Gain of Radiotherapy.靶向免疫调节 CD73/腺苷系统以提高放射治疗的疗效增益。
Front Immunol. 2019 Apr 5;10:698. doi: 10.3389/fimmu.2019.00698. eCollection 2019.
10
A Novel Specific Anti-CD73 Antibody Inhibits Triple-Negative Breast Cancer Cell Motility by Regulating Autophagy.一种新型特异性抗 CD73 抗体通过调控自噬抑制三阴性乳腺癌细胞迁移。
Int J Mol Sci. 2019 Feb 28;20(5):1057. doi: 10.3390/ijms20051057.
引用本文的文献
1
Immunotherapy Resistance in Glioblastoma.胶质母细胞瘤中的免疫治疗耐药性
Front Genet. 2021 Dec 17;12:750675. doi: 10.3389/fgene.2021.750675. eCollection 2021.
2
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives.嘌呤和嘧啶核苷酸与人胞外 5′-核苷酸酶（CD73）的结合模式及其双膦酸衍生物的抑制作用。
Purinergic Signal. 2021 Dec;17(4):693-704. doi: 10.1007/s11302-021-09802-w. Epub 2021 Aug 17.
3
Prognostic value of CD73 expression in resected colorectal cancer liver metastasis.CD73表达在切除的结直肠癌肝转移中的预后价值。
Oncoimmunology. 2020 Apr 23;9(1):1746138. doi: 10.1080/2162402X.2020.1746138. eCollection 2020.
4
JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer.JAK/Stat5 介导的亚型特异性淋巴细胞抗原 6 复合物，基因座 G6D（LY6G6D）表达驱动错配修复有效的结直肠癌。
J Exp Clin Cancer Res. 2019 Jan 22;38(1):28. doi: 10.1186/s13046-018-1019-5.
5
Prognositic value of CD73-adenosinergic pathway in solid tumor: A meta-analysis and systematic review.CD73-腺苷能通路在实体瘤中的预后价值：一项荟萃分析与系统评价
Oncotarget. 2017 Apr 6;8(34):57327-57336. doi: 10.18632/oncotarget.16905. eCollection 2017 Aug 22.
6
Tiamulin inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of CD73.替米考星通过降低CD73的活性来抑制乳腺癌的生长和肺转移。
BMC Cancer. 2017 Apr 11;17(1):255. doi: 10.1186/s12885-017-3250-4.
7
CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer.CD73/NT5E是miR-30a-5p的一个靶点，在非小细胞肺癌的发病机制中起重要作用。
Mol Cancer. 2017 Feb 3;16(1):34. doi: 10.1186/s12943-017-0591-1.
8
MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma.微小RNA-422a通过靶向头颈部鳞状细胞癌中的NT5E/CD73促进局部区域复发。
Oncotarget. 2016 Jul 12;7(28):44023-44038. doi: 10.18632/oncotarget.9829.
9
Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer.结直肠癌中与癌症相关的免疫抵抗及免疫监视逃逸
Gastroenterol Res Pract. 2016;2016:6261721. doi: 10.1155/2016/6261721. Epub 2016 Feb 23.
10
Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration.CD73基因敲除小鼠中A3、A2A和A1腺苷受体的特异性激活影响B16F10黑色素瘤的生长、新生血管形成、血管生成及巨噬细胞浸润。
PLoS One. 2016 Mar 10;11(3):e0151420. doi: 10.1371/journal.pone.0151420. eCollection 2016.
本文引用的文献
1
CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice.CD73 在非造血细胞和造血细胞中具有不同的作用，促进了小鼠肿瘤的生长。
J Clin Invest. 2011 Jun;121(6):2371-82. doi: 10.1172/JCI45559. Epub 2011 May 2.
2
Altered purinergic signaling in CD73-deficient mice inhibits tumor progression.CD73 缺陷型小鼠的嘌呤能信号改变抑制肿瘤进展。
Eur J Immunol. 2011 May;41(5):1231-41. doi: 10.1002/eji.201041292.
3
CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis.CD73 缺陷型小鼠具有增强的抗肿瘤免疫能力，并对实验性转移具有抗性。
Cancer Res. 2011 Apr 15;71(8):2892-900. doi: 10.1158/0008-5472.CAN-10-4246. Epub 2011 Feb 3.
4
NT5E mutations and arterial calcifications.NT5E 突变与动脉钙化。
N Engl J Med. 2011 Feb 3;364(5):432-42. doi: 10.1056/NEJMoa0912923.
5
Extracellular adenosine triphosphate and adenosine in cancer.细胞外三磷酸腺苷和腺苷在癌症中的作用。
Oncogene. 2010 Sep 30;29(39):5346-58. doi: 10.1038/onc.2010.292. Epub 2010 Jul 26.
6
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression.肿瘤细胞上的 CD73 抑制抗肿瘤 T 细胞反应：肿瘤诱导免疫抑制的新机制。
Cancer Res. 2010 Mar 15;70(6):2245-55. doi: 10.1158/0008-5472.CAN-09-3109. Epub 2010 Feb 23.
7
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis.抗 CD73 抗体治疗抑制乳腺癌生长和转移。
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1547-52. doi: 10.1073/pnas.0908801107. Epub 2010 Jan 4.
8
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.树突状细胞中NLRP3炎性小体的激活诱导针对肿瘤的白细胞介素-1β依赖性适应性免疫。
Nat Med. 2009 Oct;15(10):1170-8. doi: 10.1038/nm.2028. Epub 2009 Sep 20.
9
A2A adenosine receptor protects tumors from antitumor T cells.A2A 腺苷受体保护肿瘤免受抗肿瘤 T 细胞的攻击。
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13132-7. doi: 10.1073/pnas.0605251103. Epub 2006 Aug 17.
10
Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia.胞外5'-核苷酸酶（CD73）在缺氧期间血管渗漏中的关键作用。
J Exp Med. 2004 Dec 6;200(11):1395-405. doi: 10.1084/jem.20040915.
Zotero 插件