疫苗接种途径对黏膜部位肿瘤消退的影响是什么？
What is the influence of vaccination's routes on the regression of tumors located at mucosal sites?
机构信息
Department of Urology; Centre Hospitalier Universitaire Vaudois; Lausanne, Switzerland.
出版信息
Oncoimmunology. 2012 Mar 1;1(2):242-243. doi: 10.4161/onci.1.2.18204.
Abstract
Tumor-regressions following tumor-associated-antigen vaccination in animal models contrast with the limited clinical outcomes in cancer patients. Most animal studies however used subcutaneous-tumor-models and questions arise as whether these are relevant for tumors growing in mucosae; whether specific mucosal-homing instructions are required; and how this may be influenced by the tumor.
摘要
在动物模型中，肿瘤相关抗原疫苗接种后会出现肿瘤消退，但在癌症患者中临床疗效有限。然而，大多数动物研究使用的是皮下肿瘤模型，人们不禁会产生疑问，这些模型是否与黏膜生长的肿瘤相关；是否需要特定的黏膜归巢指令；以及肿瘤可能会对此产生怎样的影响。
Zotero 插件