宿主 CD73 会损害抗肿瘤免疫。
Host CD73 impairs anti-tumor immunity.
机构信息
MediCity Research Laboratory; University of Turku; Turku, Finland ; Department of Medical Biochemistry and Genetics; University of Turku; Turku, Finland ; National Institute of Health and Welfare; Tykistökatu; Turku, Finland.
出版信息
Oncoimmunology. 2012 Mar 1;1(2):247-248. doi: 10.4161/onci.1.2.18310.
The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for the anti-tumor immunity.
CD73 的酶活性产生具有免疫抑制作用的腺苷。在 CD73 缺陷型宿主中，肿瘤生长以及 Treg 和 2 型免疫抑制性巨噬细胞浸润肿瘤的现象减少。在野生型小鼠中，用药物抑制 CD73 也具有类似的肿瘤抑制作用。因此，宿主白细胞和内皮细胞上的 CD73 不利于抗肿瘤免疫。
Zotero 插件