McKenna R W, Allison P M
Department of Pathology, University of Texas Southwestern Medical Center, Dallas.
Clin Lab Med. 1990 Dec;10(4):683-706.
The myelodysplastic syndromes are bone marrow stem cell disorders that result in disorderly and ineffective hematopoiesis. They are prognostically heterogenous. Approximately one third of cases evolve to acute myeloid leukemia. Many additional cases terminate in severe bone marrow failure. The French-American-British Working Group classification of the myelodysplastic syndromes defines morphologic and prognostic groups. Cytogenetic and in vitro cell culture characteristics are important prognostic indicators.
骨髓增生异常综合征是骨髓干细胞疾病，可导致造血紊乱且无效。其预后具有异质性。约三分之一的病例会进展为急性髓系白血病。许多其他病例最终会发展为严重的骨髓衰竭。法美英工作组对骨髓增生异常综合征的分类定义了形态学和预后分组。细胞遗传学和体外细胞培养特征是重要的预后指标。
