Kampmeier P, Anastasi J, Vardiman J W
Department of Pathology, University of Chicago Medical Center, Illinois.
Hematol Oncol Clin North Am. 1992 Jun;6(3):501-22.
The diagnosis and subclassification of myelodysplastic syndromes (MDS) are usually straightforward if the criteria established by the French-American-British Cooperative Group are carefully followed. Some cases can be diagnostically challenging, however. This article discusses some of the special diagnostic problems such as hypocellular MDS, MDS with fibrosis, and cases that show morphologic overlap with myeloproliferative disorders and acute leukemia. Additional problems sometimes encountered in the diagnosis of MDS such as extramedullary disease, associated lymphoproliferative disease, and the 5q-syndrome are also reviewed.
如果仔细遵循法美英协作组制定的标准，骨髓增生异常综合征（MDS）的诊断和亚型分类通常很简单。然而，有些病例的诊断可能具有挑战性。本文讨论了一些特殊的诊断问题，如低细胞性MDS、伴有纤维化的MDS以及与骨髓增殖性疾病和急性白血病存在形态学重叠的病例。还回顾了MDS诊断中有时遇到的其他问题，如髓外疾病、相关的淋巴增殖性疾病和5q综合征。
