Chen Y X
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1990 Jul;12(4):281-3.
Expression of IL-2 receptor and proliferative response to rIL-2 of PBMC were studied in 48 patients with malignant diseases and in 50 normal subjects. Having been activated by PHA, PBMC from cancer patients had about the same percentage of Tac positive cells as compared with the normal subjects. However, resting and Con A-activated PBMC showed a significantly weaker proliferative response to rIL-2 in cancer patients than in normal subjects (P less than 0.001-0.005). The decrease in PBMC proliferative response to rIL-2 in patients with malignant diseases might be due to a defect in the formation of high affinity IL-2 receptors.
对48例恶性疾病患者和50名正常受试者的外周血单个核细胞（PBMC）的白细胞介素-2（IL-2）受体表达及对重组IL-2（rIL-2）的增殖反应进行了研究。经植物血凝素（PHA）激活后，癌症患者的PBMC中Tac阳性细胞的百分比与正常受试者相比大致相同。然而，静息及经刀豆蛋白A（Con A）激活的PBMC对rIL-2的增殖反应在癌症患者中明显弱于正常受试者（P＜0.001 - 0.005）。恶性疾病患者PBMC对rIL-2增殖反应的降低可能是由于高亲和力IL-2受体形成缺陷所致。
