Zhang B, Shen W X
Department of Immunology, Nanjing Institute of Medical Science.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1991;9(2):126-9.
The ability of adherent and nonadherent peripheral blood mononuclear cells (PBMC) from forty patients with schistosomiasis to produce IL-1 and IL-2 was studied. The results indicated that ConA-stimulated nonadherent-PBMC from patients exhibited a decreasing ability to produce IL-2 compared with controls (P less than 0.001), and that their ConA-activated blast cells expressed a smaller number of cell surface IL-2 receptor since IL-2 adsorption to the patient cells was lower than that to the normal cells (P less than 0.01). On the other hand, IL-1 production by LpS-stimulated adherent-PBMC from the patients was in agreement with that from the normal controls (P greater than 0.05). From above results, it seems that human organism following infection of Schistosoma japonicum might display a sort of suppressive phenomenon in the production of and the response to IL-2.
对40例血吸虫病患者的贴壁和非贴壁外周血单个核细胞（PBMC）产生白细胞介素-1（IL-1）和白细胞介素-2（IL-2）的能力进行了研究。结果表明，与对照组相比，来自患者的经刀豆蛋白A（ConA）刺激的非贴壁PBMC产生IL-2的能力下降（P<0.001），并且其ConA激活的母细胞表达的细胞表面IL-2受体数量较少，因为IL-2吸附到患者细胞上的量低于正常细胞（P<0.01）。另一方面，来自患者的经脂多糖（LpS）刺激的贴壁PBMC产生IL-1的情况与正常对照组一致（P>0.05）。从上述结果来看，感染日本血吸虫后的人体似乎在IL-2的产生及对IL-2的反应方面表现出一种抑制现象。
