Watanabe M
Acta Med Okayama. 1979 Aug;33(4):269-85.
The alterations of lipid composition in sera of patients with liver diseases, particularly intrahepatic cholestasis and biliary obstruction, were studied by ultracentrifugation and polyacrylamide-gel disc-electrophoresis of lipoproteins and apoproteins. The elevation of serum cholesterol in intrahepatic cholestasis was greater than in biliary obstruction. The appearance of lipoprotein X in obstructive disease accounted for most of the increased cholesterol. The level of non-lipoprotein X cholesterol in intrahepatic cholestasis was significantly elevated, this being in part ascribed to the appearance of a new class of cholestatic lipoprotein, Slow-migrating HDL. The electrophoretic pattern of lipoprotein in cholestasis was generally characterized by a decrease in alpha band intensity and, in some types of cholestasis, by the appearance of Slow-migrating HDL. In addition, other abnormal lipoproteins exhibiting the characteristics of triglyceride-rich LDL (LP-Y), LP-X-like HDL and LDL-like HDL were found in some cases of intrahepatic cholestasis and biliary obstruction.
通过对脂蛋白和载脂蛋白进行超速离心及聚丙烯酰胺凝胶圆盘电泳，研究了肝病患者，尤其是肝内胆汁淤积和胆道梗阻患者血清中脂质成分的变化。肝内胆汁淤积患者血清胆固醇的升高幅度大于胆道梗阻患者。梗阻性疾病中脂蛋白X的出现是胆固醇升高的主要原因。肝内胆汁淤积中非脂蛋白X胆固醇水平显著升高，部分原因是出现了一类新的胆汁淤积性脂蛋白，即慢迁移高密度脂蛋白（Slow-migrating HDL）。胆汁淤积时脂蛋白的电泳图谱通常表现为α带强度降低，在某些类型的胆汁淤积中，还会出现慢迁移高密度脂蛋白。此外，在一些肝内胆汁淤积和胆道梗阻病例中还发现了其他异常脂蛋白，它们具有富含甘油三酯的低密度脂蛋白（LP-Y）、脂蛋白X样高密度脂蛋白和低密度脂蛋白样高密度脂蛋白的特征。
