Watanabe M, Taketa K, Nagashima H, Yamamoto Y
Acta Med Okayama. 1979 Aug;33(4):323-6.
In cardiovascular diseases with potential atherosclerosis, the serum concentration of HDL cholesterol as determined by a precipitation method with dextran sulfate and Mg++ was lower while that of total cholesterol was normal or elevated. Treatment with a daily dose of 1,200 mg of Nicomol, a derivative of nicotinic acid, for 1 to 3 months increased the mean HDL cholesterol level by 3 to 5 mg/dl and reduced the total cholesterol level by 14 to 15 mg/dl and total/HDL cholesterol ratio by 0.8 (3 months) to 0.9 (1 month, p less than 0.05). Similar decreases in HDL cholesterol concentration were also found in parenchymal and obstructive liver diseases with normal total cholesterol values except in fulminant hepatitis and intrahepatic cholestasis.
在伴有潜在动脉粥样硬化的心血管疾病中，用硫酸葡聚糖和镁离子沉淀法测定的血清高密度脂蛋白胆固醇浓度较低，而总胆固醇浓度正常或升高。每日服用1200毫克烟酸衍生物尼可莫尔，治疗1至3个月，可使平均高密度脂蛋白胆固醇水平升高3至5毫克/分升，总胆固醇水平降低14至15毫克/分升，总胆固醇/高密度脂蛋白胆固醇比值降低0.8（3个月）至0.9（1个月，p小于0.05）。在总胆固醇值正常的实质性和阻塞性肝病中，除暴发性肝炎和肝内胆汁淤积外，也发现高密度脂蛋白胆固醇浓度有类似下降。
