5-羟色胺3受体的拮抗作用可减弱乙醇对细胞外多巴胺的影响。
Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine.
作者信息
Wozniak K M, Pert A, Linnoila M
机构信息
LCS/NIAAA, NIH Clinical Center, Bethesda, MD 20892.
出版信息
Eur J Pharmacol. 1990 Oct 9;187(2):287-9. doi: 10.1016/0014-2999(90)90015-x.
PMID:2272364
Abstract
The effect of a 5-HT3 antagonist, ICS 205-930, on ethanol-induced changes in extracellular dopamine, was investigated with in vivo microdialysis. Pretreatment of rats with ICS 205-930 effectively attenuated the subsequent increases in dopamine, in both the nucleus accumbens and corpus striatum. This suggests that 5-HT may be involved in the effects of ethanol on dopaminergic systems.
摘要
采用体内微透析技术研究了5-羟色胺3（5-HT3）拮抗剂ICS 205-930对乙醇诱导的细胞外多巴胺变化的影响。用ICS 205-930预处理大鼠可有效减弱随后伏隔核和纹状体内多巴胺的增加。这表明5-羟色胺可能参与了乙醇对多巴胺能系统的作用。
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