Armenian A R, Arakelian L N, Aprikian G V
Institute of Biochemistry, Academy of Sciences of the Armenian SSR, Yerevan.
Fiziol Zh (1978). 1990 Sep-Oct;36(5):50-4.
The uptake and K(+)-evoked (40 mM) release of 3H-norepinephrine (3H-NE) in mesodiencephalic synaptosomes of adult and senescent rats and the effect of N-acetylaspartic acid (NAA) on these processes have been studied. It has been shown that the uptake of 3H-NE by old rats is reduced considerably. The K(+)-evoked release of 3H-NE from rats synaptosomes is significantly decreased in aged rats. In the presence of 10(-4)-3.10(-3) M NAA the uptake of 3H-NE by adult and senescent rats synaptosomes remains unchanged. In these concentrations NAA inhibits the K(+)-evoked release of 3H-NE from synaptosomes of adult rats, but it exerts no effect on this process in senescent rats.
研究了成年和老年大鼠中脑间脑突触体对³H-去甲肾上腺素（³H-NE）的摄取以及K⁺（40 mM）诱发的³H-NE释放，以及N-乙酰天门冬氨酸（NAA）对这些过程的影响。结果表明，老年大鼠对³H-NE的摄取显著降低。老年大鼠突触体中K⁺诱发的³H-NE释放明显减少。在10⁻⁴ - 3×10⁻³ M NAA存在的情况下，成年和老年大鼠突触体对³H-NE的摄取保持不变。在这些浓度下，NAA抑制成年大鼠突触体中K⁺诱发的³H-NE释放，但对老年大鼠的这一过程没有影响。
