Viinamäki Heimo, Lehto Soili M, Palvimo Jorma J, Harvima Ilkka, Valkonen-Korhonen Minna, Koivumaa-Honkanen Heli, Hintikka Jukka, Kirsi Honkalampi, Niskanen Leo
Duodecim. 2012;128(10):1022-9.
Current research interest is increasingly directed towards the role of glucocorticoid actions and inflammation. A failure in the stress system regulation appears to largely characterize depression. New research data have substantially diversified the theoretical concept of association between overactivity of HPA-axis and depression. The glucocorticoid effects are regulated by glucocorticoid reseptor gene polymorphisms, and glucocorticoid resistance is often associated with depression. Moreover, immune system disturbances affect the development of depression, and an altered balance of pro- and anti-inflammatory cytokines is also observable. Treatment methods that follow the new developments of the glucocorticoid theory are being developed.
当前的研究兴趣越来越多地指向糖皮质激素作用与炎症的关系。应激系统调节功能的失效似乎在很大程度上是抑郁症的特征。新的研究数据极大地丰富了下丘脑-垂体-肾上腺（HPA）轴功能亢进与抑郁症之间关联的理论概念。糖皮质激素的作用受糖皮质激素受体基因多态性的调节，糖皮质激素抵抗常与抑郁症相关。此外，免疫系统紊乱会影响抑郁症的发展，促炎细胞因子和抗炎细胞因子平衡的改变也很明显。遵循糖皮质激素理论新进展的治疗方法正在研发中。
