Cubała Wiesław Jerzy, Godlewska Beata, Trzonkowski Piotr, Landowski Jerzy
Klinika Chorób Psychicznych i Zaburzeń Nerwicowych Katedry Chorób Psychicznych AM w Gdańsku.
Psychiatr Pol. 2006 May-Jun;40(3):431-44.
The aetiology of depression remains tentative. Current hypotheses on the aetiology of the depressive disorder tend to integrate monoaminoergic, neuroendocrine and immunological concepts of depression. A number of research papers emphasise the altered hormonal and immune status of patients with depression with pronounced cytokine level variations. Those studies tend to link the variable course of depression in relation to the altered proinflammatory activity of the immune system. The results of the studies on the activity of the selected elements of the immune system are ambiguous indicating both increased and decreased activities of its selected elements. However, a number of basic and psychopharmacological studies support the hypothesis of the increased proinflammatory activity of the immune system in the course of depression which is the foundation for the immunological hypothesis of depression. The aim of this paper is to review the functional abnormalities that are observed in depression focusing on the monoaminoergic deficiency and increased immune activation as well as endocrine dysregulation. This paper puts together and discusses current studies related to this subject with a detailed insight into interactions involving nervous, endocrine and immune systems.
抑郁症的病因仍不明确。目前关于抑郁症病因的假说倾向于整合抑郁症的单胺能、神经内分泌和免疫概念。许多研究论文强调抑郁症患者激素和免疫状态的改变以及细胞因子水平的显著变化。这些研究倾向于将抑郁症的变化过程与免疫系统促炎活性的改变联系起来。关于免疫系统特定成分活性的研究结果并不明确，显示其特定成分的活性既有增加也有降低。然而，一些基础和精神药理学研究支持抑郁症过程中免疫系统促炎活性增加的假说，这是抑郁症免疫假说的基础。本文旨在综述抑郁症中观察到的功能异常，重点关注单胺能缺乏、免疫激活增加以及内分泌失调。本文汇总并讨论了与该主题相关的当前研究，并深入探讨了涉及神经、内分泌和免疫系统的相互作用。
