Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran.
Arch Iran Med. 2012 Jul;15(7):400-3.
Data regarding the influence of minor changes in thyroid function on body mass index (BMI) are scarce and conflicting. This study aims to evaluate the association between normal levels of serum TSH and BMI, taking into consideration the effect of smoking tobacco.
In this cross-sectional community-based survey, 1581 randomly selected subjects who had no histories of thyroid disorders were studied within the framework of the Tehran Lipid and Glucose Study. Serum TSH and TPOAb were measured from the fasting serum samples. Weight and height were measured and BMI was calculated.
TSH concentrations within the reference range were positively associated with BMI (P < 0.002). Each unit increase of 1 µU/ml in TSH was associated with an increase in mean BMI of 0.31 kg/m2 (95% CI: 0.1 - 0.5, P < 0.002), an association which remained significant after adjustments for sex, physical activity, and smoking and in the subgroup with negative thyroid autoimmunity. The association between BMI and TSH remained significant only in nonsmokers (P < 0.004).
The results suggest that a significant positive association exists between TSH and BMI in euthyroid nonsmokers.
关于甲状腺功能的微小变化对体重指数（BMI）的影响的数据很少且相互矛盾。本研究旨在评估血清 TSH 正常水平与 BMI 之间的关系，同时考虑到吸烟的影响。
在这项基于社区的横断面研究中，我们在德黑兰血脂和血糖研究的框架内研究了 1581 名无甲状腺疾病史的随机选择的受试者。从空腹血清样本中测量血清 TSH 和 TPOAb。测量体重和身高并计算 BMI。
参考范围内的 TSH 浓度与 BMI 呈正相关（P < 0.002）。TSH 每增加 1µU/ml，平均 BMI 增加 0.31kg/m2（95%CI：0.1-0.5，P < 0.002），调整性别、体力活动和吸烟后，这种关联仍然显著，在甲状腺自身免疫阴性的亚组中也是如此。BMI 与 TSH 之间的关联仅在不吸烟者中仍然显著（P < 0.004）。
结果表明，在甲状腺功能正常的非吸烟者中，TSH 与 BMI 之间存在显著的正相关关系。
