Nyrnes A, Jorde R, Sundsfjord J
Department of Geriatric Medicine, University Hospital of North Norway, Tromsø.
Int J Obes (Lond). 2006 Jan;30(1):100-5. doi: 10.1038/sj.ijo.0803112.
To investigate whether there is an association between serum thyroid-stimulating hormone (TSH) within the normal range and body mass index (BMI).
The study was performed in 6164 subjects (2813 males) who attended the fifth Tromsø study in 2001, and in 1867 subjects (873 males) that attended both the fourth Tromsø study in 1994/1995 as well as the fifth Tromsø study.
Height, weight, and serum TSH were measured in all subjects, and smoking status was recorded.
Smokers and nonsmokers were analyzed separately. In the fifth Tromsø study, serum TSH was positively and significantly associated with BMI in the nonsmokers. Within the normal TSH range (defined as the 2.5-97.5 percentile), nonsmoking males in the highest TSH quartile had a mean BMI 0.4 kg/m(2) higher compared to those in the lower quartile, whereas the difference for nonsmoking women was 1.4 kg/m(2). Similarly, in nonsmokers in the longitudinal study, there was a significant and positive association between delta serum TSH (serum TSH in 2001 minus serum TSH in 1994) and delta BMI in those with serum TSH within the normal range both in 1994 and 2001. In these subjects, the quartile with the highest delta serum TSH had a mean increase in BMI from 1994 to 2001 that was 0.3 kg/m(2) higher compared to those in the quartile with the lowest delta serum TSH. For the smokers, relations between serum TSH and BMI were not statistically significant.
In nonsmokers there is a positive association between serum TSH within the normal range and BMI.
研究正常范围内的血清促甲状腺激素（TSH）与体重指数（BMI）之间是否存在关联。
该研究纳入了2001年参加第五次特罗姆瑟研究的6164名受试者（2813名男性），以及1994/1995年参加第四次特罗姆瑟研究且2001年又参加第五次特罗姆瑟研究的1867名受试者（873名男性）。
测量所有受试者的身高、体重和血清TSH，并记录吸烟状况。
吸烟者和非吸烟者分别进行分析。在第五次特罗姆瑟研究中，非吸烟者的血清TSH与BMI呈显著正相关。在正常TSH范围内（定义为第2.5至97.5百分位数），TSH处于最高四分位数的非吸烟男性的平均BMI比处于最低四分位数的男性高0.4kg/m²，而非吸烟女性的这一差值为1.4kg/m²。同样，在纵向研究的非吸烟者中，1994年和2001年血清TSH均在正常范围内的受试者，其血清TSH变化值（2001年血清TSH减去1994年血清TSH）与BMI变化值之间存在显著正相关。在这些受试者中，血清TSH变化值最高的四分位数组从1994年到2001年的BMI平均增加量比血清TSH变化值最低的四分位数组高0.3kg/m²。对于吸烟者，血清TSH与BMI之间的关系无统计学意义。
在非吸烟者中，正常范围内的血清TSH与BMI之间存在正相关。
