备解素因子补体基因座Pfc在小鼠X染色体A3带的定位。

Localization of the properdin factor complement locus Pfc to band A3 on the mouse X chromosome.

作者信息

Evans E P, Burtenshaw M D, Laval S H, Goundis D, Reid K B, Boyd Y

机构信息

Sir William Dunn School of Pathology, Oxford, U.K.

出版信息

Genet Res. 1990 Oct-Dec;56(2-3):153-5. doi: 10.1017/s0016672300035230.

DOI:10.1017/s0016672300035230

PMID:2272504

Abstract

The locus for properdin (properdin factor complement, Pfc), a plasma glycoprotein, has been mapped to band A3 of the mouse X chromosome by in situ hybridization to metaphase spreads containing an X;2 Robertsonian translocation. The X-linkage of the locus has also been confirmed by analysis of Mus musculus x Mus spretus interspecific crosses. The XA3 localization for Pfc places it in the chromosomal segment conserved between man and mouse which is known to contain at least six other homologous loci (Cybb, Otc, Syn-1 Maoa, Araf, Timp).

摘要

备解素（备解素因子补体，Pfc）是一种血浆糖蛋白，通过对含有X;2罗伯逊易位的中期染色体铺展进行原位杂交，已将其基因座定位到小鼠X染色体的A3带。该基因座的X连锁也通过小家鼠与西班牙小鼠种间杂交分析得到证实。Pfc的XA3定位使其处于人和小鼠之间保守的染色体区段，已知该区段至少还包含其他六个同源基因座（Cybb、Otc、Syn-1、Maoa、Araf、Timp）。