Department of Sciences for Health Promotion G. D'Alessandro, University of Palermo, Via Del Vespro 133, Palermo, I-90127, Italy.
Int J Infect Dis. 2012 Aug;16(8):e633-5. doi: 10.1016/j.ijid.2012.04.012. Epub 2012 Jun 21.
High Toscana virus (TOSV) antibody seropositivity rates have been documented in the last decade, especially in the Mediterranean area. It is unclear if these rates are associated with a recent or past exposure to the virus. This is of importance, as primary infection can cause neurologic complications, especially in adults. The aim of the present study was to assess the current active TOSV circulation in western Sicily.
A cross-sectional seroprevalence study was conducted on 271 individuals aged 4-92 years, sampled from the general population of a small city. Each participant completed a self-administered questionnaire and provided serum, which was analyzed for the presence of specific anti-TOSV IgM and IgG.
Anti-TOSV IgM was detected in eight (3.0%) participants, of whom only three had anti-TOSV IgG. The prevalence of anti-TOSV IgM was highest in subjects aged 25-34 and 35-44 years (7.1% and 4.8%, respectively). All subjects positive for anti-TOSV IgM were resident in the suburban area.
The detection of IgM documented the circulation of TOSV, a Phlebovirus, in a random population sample of Sicilian adults. The highest risk of TOSV seroconversion in subjects living in the suburbs appears to suggest a high density of TOSV vectors in peri-urban areas.
过去十年中，高托斯卡纳病毒（TOSV）抗体阳性率在文献中被多次记录，特别是在地中海地区。目前尚不清楚这些阳性率是否与近期或过去的病毒暴露有关。这一点很重要，因为原发性感染可能导致神经并发症，尤其是在成年人中。本研究旨在评估西西西里岛目前 TOSV 的活跃传播情况。
对来自一个小城市的一般人群中的 271 名年龄在 4-92 岁的个体进行了横断面血清流行率研究。每个参与者都完成了一份自我管理的问卷，并提供了血清，以分析是否存在特定的抗 TOSV IgM 和 IgG。
在 8 名（3.0%）参与者中检测到抗 TOSV IgM，其中只有 3 名有抗 TOSV IgG。在 25-34 岁和 35-44 岁的人群中，抗 TOSV IgM 的患病率最高（分别为 7.1%和 4.8%）。所有抗 TOSV IgM 阳性的受试者均居住在郊区。
IgM 的检测记录了 TOSV（一种黄病毒）在西西里岛成年人群体随机样本中的传播。居住在郊区的个体 TOSV 血清转化率最高，这表明城市周边地区 TOSV 载体密度较高。
