Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Am J Obstet Gynecol. 2012 Jul;207(1):46.e1-8. doi: 10.1016/j.ajog.2012.04.030. Epub 2012 May 2.
The objective of the study was to examine the association between lactation and maternal subclinical cardiovascular disease.
The Women and Infants Study of Healthy Hearts enrolled 607 mothers who delivered a singleton between 1997 and 2002. In 2007, participating mothers underwent measurements of carotid intima-media thickness, lumen diameter, adventitial diameter, and carotid-femoral pulse wave velocity. Multivariable linear and logistic regressions were used to estimate the associations between lactation and subclinical cardiovascular disease.
Compared with mothers who breastfed for 3 or more months after every birth, mothers who never breastfed exhibited a 0.13 mm larger lumen diameter (95% confidence interval, 0.04-0.22) and a 0.12 mm larger adventitial diameter (95% confidence interval, 0.02-0.22) in models adjusting for age, parity, birth outcome, sociodemographic variables, health-related behaviors, family history, gestational weight gain, early adult body mass index, current body mass index, C-reactive protein, blood pressure, cholesterol, triglyceride, high-density lipoprotein, glucose, and insulin levels.
Mothers who do not breastfeed have vascular characteristics associated with a greater risk of cardiovascular disease.
本研究旨在探讨哺乳与产妇亚临床心血管疾病之间的关系。
健康心脏母婴研究纳入了 1997 年至 2002 年间分娩的 607 位单胎母亲。2007 年，参与研究的母亲接受了颈动脉内膜中层厚度、管腔直径、外膜直径和颈动脉-股动脉脉搏波速度的测量。采用多变量线性和逻辑回归模型来估计哺乳与亚临床心血管疾病之间的关联。
与每次分娩后至少哺乳 3 个月的母亲相比，从不哺乳的母亲在调整年龄、产次、分娩结局、社会人口学变量、健康相关行为、家族史、妊娠体重增加、成年早期体重指数、当前体重指数、C 反应蛋白、血压、胆固醇、甘油三酯、高密度脂蛋白、葡萄糖和胰岛素水平后，其管腔直径大 0.13 毫米（95%置信区间，0.04-0.22），外膜直径大 0.12 毫米（95%置信区间，0.02-0.22）。
不哺乳的母亲具有与心血管疾病风险增加相关的血管特征。
