成纤维细胞生长因子 23 和白细胞介素 6 是腹膜透析患者左心室肥厚的危险因素。

Fibroblast growth factor-23 and interleukin-6 are risk factors for left ventricular hypertrophy in peritoneal dialysis patients.

机构信息

Department of Nephrology, Fujian Provincial Hospital, Fuzhou, China.

出版信息

J Cardiovasc Med (Hagerstown). 2012 Sep;13(9):565-9. doi: 10.2459/JCM.0b013e3283536859.

DOI:10.2459/JCM.0b013e3283536859

PMID:22728833

Abstract

BACKGROUND

Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular death in dialysis patients. Fibroblast growth factor-23 (FGF-23) and interleukin-6 (IL-6) were thought to be related to cardiovascular diseases (CVDs) in dialysis.

METHODS

To determine the relationship between FGF-23, IL-6 and LVH in continuous ambulatory peritoneal dialysis (CAPD) patients, serum FGF-23 and IL-6 levels as well as standard laboratory parameters were assessed in 62 CAPD patients and 30 healthy controls. LVH was determined by echocardiography in dialysis patients.

RESULTS

Serum FGF-23 and IL-6 levels were significantly higher in CAPD patients than in healthy controls, whereas both were higher in patients with LVH than in patients without LVH. FGF-23 was found to be positively associated with left ventricle mass index (LVMI) and serum phosphate. IL-6 level was positively associated with LVMI and negatively correlated with serum albumin and hemoglobin. Serum FGF-23 level was positively correlated with IL-6 level.

CONCLUSION

FGF-23 and IL-6 are independent risk factors for LVH in CAPD patients and both collaborated in causing LVH in CAPD.

摘要

背景

左心室肥厚（LVH）是透析患者心血管死亡的主要危险因素。成纤维细胞生长因子 23（FGF-23）和白细胞介素 6（IL-6）被认为与透析患者的心血管疾病（CVD）有关。

方法

为了确定成纤维细胞生长因子 23（FGF-23）、白细胞介素 6（IL-6）与持续非卧床腹膜透析（CAPD）患者左心室肥厚（LVH）之间的关系，评估了 62 例 CAPD 患者和 30 例健康对照者的血清 FGF-23 和 IL-6 水平以及标准实验室参数。在透析患者中通过超声心动图确定 LVH。

结果

与健康对照组相比，CAPD 患者的血清 FGF-23 和 IL-6 水平显著升高，而 LVH 患者的 FGF-23 和 IL-6 水平均高于无 LVH 患者。FGF-23 与左心室质量指数（LVMI）和血清磷酸盐呈正相关。IL-6 水平与 LVMI 呈正相关，与血清白蛋白和血红蛋白呈负相关。血清 FGF-23 水平与 IL-6 水平呈正相关。