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正常和软骨发育不全(cn/cn)小鼠生长板中的动力学参数。

Kinetic parameters in the growth plate of normal and achondroplastic (cn/cn) mice.

作者信息

Sannasgala S S, Johnson D R

机构信息

Department of Anatomy, University of Leeds, West Yorks, UK.

出版信息

J Anat. 1990 Oct;172:245-58.

PMID:2272905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1257219/
Abstract

We have reinvestigated the overall size, zone size, mitotic rate and growth rate in the tibial epiphysis of normal and achondroplastic (cn/cn) mice aged 7-55 days. Our present sample did not contain the two phenotypes characteristic of some stocks carrying the gene: cn/cn mice showed smaller zone sizes within the growth plates, smaller cells, decreased mitotic indices and growth rates.

摘要

我们重新研究了7至55日龄正常和软骨发育不全(cn/cn)小鼠胫骨骨骺的整体大小、区域大小、有丝分裂率和生长速率。我们目前的样本不包含携带该基因的某些品系所特有的两种表型:cn/cn小鼠生长板内的区域较小,细胞较小,有丝分裂指数和生长速率降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d318/1257219/a15485889ac8/janat00038-0252-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d318/1257219/a15485889ac8/janat00038-0252-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d318/1257219/a15485889ac8/janat00038-0252-a.jpg

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Kinetic parameters in the growth plate of normal and achondroplastic (cn/cn) mice.正常和软骨发育不全(cn/cn)小鼠生长板中的动力学参数。
J Anat. 1990 Oct;172:245-58.
2
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本文引用的文献

1
Cell division in endochondral ossification. A study of cell proliferation in rat bones by the method of tritiated thymidine autoradiography.软骨内成骨中的细胞分裂。用氚标记胸腺嘧啶核苷放射自显影法对大鼠骨骼细胞增殖的研究。
J Bone Joint Surg Br. 1960 Nov;42B:824-39.
2
Three recessive mutations producing disproportionate dwarfing in mice: achondroplasia, brachymorphic, and stubby.三种导致小鼠不成比例侏儒症的隐性突变:软骨发育不全、短体型和短粗型。
J Hered. 1968 Sep-Oct;59(5):300-8. doi: 10.1093/oxfordjournals.jhered.a107725.
3
Abnormal growth of the body, internal organs and skeleton in the achondroplastic mice.
Acta Biol Acad Sci Hung. 1970;21(4):347-54.
4
Comparative patterns of cell division in epiphyseal cartilage plates in the rat.大鼠骨骺软骨板中细胞分裂的比较模式
J Anat. 1972 Jan;111(Pt 1):137-42.
5
Cell population kinetics of bone growth: the first ten years of autoradiographic studies with tritiated thymidine.骨生长的细胞群体动力学:用氚标记胸腺嘧啶核苷进行放射自显影研究的头十年。
Clin Orthop Relat Res. 1971 May;76:213-30. doi: 10.1097/00003086-197105000-00029.
6
Growth-plate-chondrocyte profiles and their orientation.生长板软骨细胞形态及其取向。
J Bone Joint Surg Am. 1985 Jul;67(6):942-55.
7
Cell kinetics of growth cartilage of achondroplastic (cn) mice.软骨发育不全(cn)小鼠生长软骨的细胞动力学
J Anat. 1985 May;140 ( Pt 3)(Pt 3):425-34.
8
Skeletal growth and development of achondroplastic mice.软骨发育不全小鼠的骨骼生长与发育
Growth. 1975 Mar;39(1):17-33.
9
Histological and histochemical investigations of achondroplastic mice: a possible model of human achondroplasia.软骨发育不全小鼠的组织学和组织化学研究:人类软骨发育不全的一种可能模型。
Growth. 1976 Sep;40(3):241-51.
10
Ultrastructure of articular cartilage of achondroplastic mice.软骨发育不全小鼠关节软骨的超微结构
Acta Anat (Basel). 1976;96(2):162-75. doi: 10.1159/000144670.