Silberberg R, Hasler M, Lesker P
Acta Anat (Basel). 1976;96(2):162-75. doi: 10.1159/000144670.
Articular chondrocytes of achondroplastic mice (cn/cn) resemble ultrastructurally those of their non-achondroplastic siblings (Cn/Cn or Cn/cn), except for premature deposition of glycogen and a tendency to undergo regression. The latter may be slight or extreme. The ultimate cause of the vulnerability of the chondrocytes and the cause of the heterogeneity of the reaction could not be determined with the method employed. Nevertheless, increased vulnerability accounts for cell death under conditions which are usually not injurious, and which may be either physiologic or altered by endogenous or exogenous factors.
软骨发育不全小鼠（cn/cn）的关节软骨细胞在超微结构上与其非软骨发育不全的同胞（Cn/Cn或Cn/cn）相似，只是糖原过早沉积且有退化倾向。后者可能轻微或严重。采用的方法无法确定软骨细胞易损性的最终原因以及反应异质性的原因。然而，易损性增加导致细胞在通常无损伤的条件下死亡，这些条件可能是生理性的，也可能因内源性或外源性因素而改变。
