Neurology, Max Planck Institute of Psychiatry, Munich, Germany.
Mult Scler. 2013 Jan;19(1):126-8. doi: 10.1177/1352458512447596. Epub 2012 Jun 22.
Fingolimod-related bradycardia is usually asymptomatic, reaches its nadir within 6 hours post-dose and recovers spontaneously. Here we report the case of a 30-year-old MS patient with vagotonia who developed symptomatic bradycardia with 33 beats per minute at nadir 39 hours after a single dose of fingolimod. Bradycardia was responsive to atropine, but returned within 2 hours. Overall, it took a week until the patient recovered. Extended monitoring is advised in patients with symptomatic bradycardia.
芬戈莫德相关的心动过缓通常无症状，在给药后 6 小时内达到最低点，并自发恢复。在此，我们报告了一例 30 岁多发性硬化症患者的病例，该患者在单次服用芬戈莫德后 39 小时出现迷走神经张力亢进导致的有症状心动过缓，最低点为 33 次/分钟。心动过缓对阿托品有反应，但在 2 小时内又恢复了。总体而言，患者需要一周时间才能恢复。对于有症状心动过缓的患者，建议进行延长监测。
