Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
J Physiol Biochem. 2013 Mar;69(1):35-43. doi: 10.1007/s13105-012-0185-8. Epub 2012 Jun 23.
Zinc has a role in the synthesis, storage, and secretion of insulin, and has been suggested to be beneficial when used in the diabetic state. Effect of zinc intake in pregnant rats has been studied here on diabetized offspring. Pregnant rats were divided in two groups; the control group received normal food and water, and the experimental group received zinc sulfate during pregnancy and 3 weeks after offspring birth. Male offspring from the control (C) and experimental (E) groups were divided each in three groups: C1, fed with normal food and water; C2, diabetized with alloxan; C3, received zinc sulfate; E1, fed with normal food and water; E2, diabetized with alloxan; and E3, receiving zinc sulfate. After 30 days, the histological changes of pancreatic tissues were investigated by light microscopy. Body weight, blood glucose, serum insulin levels, food intake, water intake, and urine quantity were also compared between the groups. Water intake and urine quantity were decreased significantly (p < 0.01 and p < 0.001) in E2 (experimental diabetic group) in comparison with C2 (control diabetic group), but there was no significant difference in the body weight in C2 in comparison with E2, while blood glucose was decreased significantly (p < 0.001) and blood insulin level was increased significantly (p < 0.01) in E2 in comparison with C2. Microscopic evaluation of pancreas showed that E2 were protected against alloxan-induced beta-cell degeneration. In conclusion, this work showed that maternal zinc intake may influence subsequent deleterious effects of diabetes on alloxan-diabetized offspring.
锌在胰岛素的合成、储存和分泌中发挥作用，并已被证明在糖尿病状态下有益。本研究探讨了给怀孕大鼠补锌对糖尿病子代的影响。将怀孕大鼠分为两组；对照组给予正常饮食和水，实验组在怀孕期间和产后 3 周给予硫酸锌。来自对照组（C）和实验组（E）的雄性子代又分为三组：C1，给予正常饮食和水；C2，用链脲佐菌素诱导糖尿病；C3，给予硫酸锌；E1，给予正常饮食和水；E2，用链脲佐菌素诱导糖尿病；E3，给予硫酸锌。30 天后，通过光镜观察胰腺组织的组织学变化。还比较了各组之间的体重、血糖、血清胰岛素水平、食物摄入量、水摄入量和尿量。与 C2（对照组糖尿病组）相比，E2（实验组糖尿病组）的水摄入量和尿量显著减少（p<0.01 和 p<0.001），但 C2 组的体重与 E2 组无显著差异，而 E2 组的血糖显著降低（p<0.001），胰岛素水平显著升高（p<0.01）。胰腺的显微镜评估表明，E2 可预防链脲佐菌素诱导的β细胞变性。总之，这项工作表明，母体锌摄入可能会影响糖尿病对链脲佐菌素诱导的糖尿病子代的后续有害影响。
