采用微创切除术、放疗和经动脉内输注 5-氟尿嘧啶治疗上颌窦癌的多学科治疗方法。

Multidisciplinary therapy consisting of minimally invasive resection, irradiation, and intra-arterial infusion of 5-fluorouracil for maxillary sinus carcinomas.

机构信息

Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University School of Medicine, Tochigi, Japan.

出版信息

Head Neck. 2013 Jun;35(6):772-8. doi: 10.1002/hed.23030. Epub 2012 Jun 23.

DOI:10.1002/hed.23030

PMID:22730109

Abstract

BACKGROUND

Current goals for the treatment of maxillary sinus carcinoma include the preservation of vision, eating, communication, and appearance, as well as the achievement of a cure.

METHODS

Japanese patients (n = 121) with maxillary sinus carcinoma were analyzed retrospectively. All patients underwent multidisciplinary therapy including minimally invasive resection, 20 Gy irradiation, and intra-arterial infusion of 5-fluorouracil.

RESULTS

The 5- and 10-year overall survival rates were 73% and 68%, respectively. In 97 patients with squamous cell carcinoma (SCC), the 5- and 10-year overall survival rates were 76% and 70%, respectively. All 29 patients with orbital invasion retained the orbital contents, and 21 of these patients demonstrated adequate visual acuity. There were 16 complications, including trismus (5 patients), double vision (5 patients), fistula formation (3 patients), and cataract (3 patients).

CONCLUSION

A multidisciplinary therapy, consisting of minimally invasive resection, irradiation, and regional chemotherapy, can yield good patient prognosis and quality of life after treatment.

摘要

背景

上颌窦癌治疗的当前目标包括保留视力、进食、交流和外貌，以及实现治愈。

方法

回顾性分析了 121 例日本上颌窦癌患者。所有患者均接受了多学科治疗，包括微创切除术、20Gy 放疗和 5-氟尿嘧啶动脉内灌注。

结果

5 年和 10 年总生存率分别为 73%和 68%。在 97 例鳞状细胞癌（SCC）患者中，5 年和 10 年总生存率分别为 76%和 70%。所有 29 例眼眶侵犯患者均保留了眶内容物，其中 21 例患者视力足够。有 16 例并发症，包括张口困难（5 例）、复视（5 例）、瘘管形成（3 例）和白内障（3 例）。