Sakashita Tomohiro, Hayashi Ryuichi, Homma Akihiro, Matsuura Kazuto, Kato Kengo, Kawabata Kazuyoshi, Monden Nobuya, Hasegawa Yasuhisa, Onitsuka Tetsuro, Fujimoto Yasushi, Iwae Shigemichi, Okami Kenji, Matsuzuka Takashi, Yoshino Kunitoshi, Fujii Masato
Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Head Neck. 2015 Apr;37(4):537-42. doi: 10.1002/hed.23639. Epub 2014 Apr 9.
The purpose of this retrospective analysis was to evaluate ocular function and survival rates among treatment modalities in patients with maxillary sinus cancer with orbital invasion.
Eighty-seven patients were classified according to the main treatment modality. Ocular function preservation rates and survival rates were evaluated for each therapeutic modality.
The 5-year overall survival rate for the en bloc resection, conservative surgery, superselective intra-arterial chemotherapy, and radiotherapy (RADPLAT), intravenous chemoradiotherapy (IV-CRT) was 70%, 35%, 49%, and 31%, respectively. The ocular function preservation rate for each group was 15%, 27%, 30%, and 17%, respectively. In the en bloc resection group, there was no significant difference in the 5-year overall survival rate between patients with orbital exenteration and those without orbital exenteration (72% vs 71%; p = .9321).
The en bloc resection group showed a favorable survival rate but a low preservation rate. Preservation of orbital contents did not reduce the survival rate.
本回顾性分析的目的是评估上颌窦癌侵犯眼眶患者不同治疗方式下的眼部功能和生存率。
87例患者根据主要治疗方式进行分类。对每种治疗方式的眼部功能保留率和生存率进行评估。
整块切除、保守手术、超选择性动脉内化疗和放疗（RADPLAT）、静脉化疗放疗（IV-CRT）的5年总生存率分别为70%、35%、49%和31%。每组的眼部功能保留率分别为15%、27%、30%和17%。在整块切除组中，行眼眶内容物剜除术的患者与未行眼眶内容物剜除术的患者5年总生存率无显著差异（72%对71%；p = 0.9321）。
整块切除组生存率良好但保留率低。保留眼眶内容物并未降低生存率。
