多机构回顾性研究：评估上颌窦鳞状细胞癌眼眶侵犯患者的眼功能保留率

Multi-institutional retrospective study for the evaluation of ocular function-preservation rates in maxillary sinus squamous cell carcinomas with orbital invasion.

作者信息

Sakashita Tomohiro, Hayashi Ryuichi, Homma Akihiro, Matsuura Kazuto, Kato Kengo, Kawabata Kazuyoshi, Monden Nobuya, Hasegawa Yasuhisa, Onitsuka Tetsuro, Fujimoto Yasushi, Iwae Shigemichi, Okami Kenji, Matsuzuka Takashi, Yoshino Kunitoshi, Fujii Masato

机构信息

Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

出版信息

Head Neck. 2015 Apr;37(4):537-42. doi: 10.1002/hed.23639. Epub 2014 Apr 9.

DOI:10.1002/hed.23639

PMID:24715544

Abstract

BACKGROUND

The purpose of this retrospective analysis was to evaluate ocular function and survival rates among treatment modalities in patients with maxillary sinus cancer with orbital invasion.

METHODS

Eighty-seven patients were classified according to the main treatment modality. Ocular function preservation rates and survival rates were evaluated for each therapeutic modality.

RESULTS

The 5-year overall survival rate for the en bloc resection, conservative surgery, superselective intra-arterial chemotherapy, and radiotherapy (RADPLAT), intravenous chemoradiotherapy (IV-CRT) was 70%, 35%, 49%, and 31%, respectively. The ocular function preservation rate for each group was 15%, 27%, 30%, and 17%, respectively. In the en bloc resection group, there was no significant difference in the 5-year overall survival rate between patients with orbital exenteration and those without orbital exenteration (72% vs 71%; p = .9321).

CONCLUSION

The en bloc resection group showed a favorable survival rate but a low preservation rate. Preservation of orbital contents did not reduce the survival rate.

摘要

背景

本回顾性分析的目的是评估上颌窦癌侵犯眼眶患者不同治疗方式下的眼部功能和生存率。

方法

87例患者根据主要治疗方式进行分类。对每种治疗方式的眼部功能保留率和生存率进行评估。

结果

整块切除、保守手术、超选择性动脉内化疗和放疗（RADPLAT）、静脉化疗放疗（IV-CRT）的5年总生存率分别为70%、35%、49%和31%。每组的眼部功能保留率分别为15%、27%、30%和17%。在整块切除组中，行眼眶内容物剜除术的患者与未行眼眶内容物剜除术的患者5年总生存率无显著差异（72%对71%；p = 0.9321）。