Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, Cali, Colombia.
Arch Pharm (Weinheim). 2012 Sep;345(9):739-44. doi: 10.1002/ardp.201100433. Epub 2012 Jun 25.
Three series of novel 8,9-dihydro-7H-pyrimido[5,4-b][1,4]diazepines, 4a-d, 5a-d, and 7a-d, were efficiently obtained in good yields using simple reaction methodologies. These pyrimidodiazepines were evaluated against 15 Mycobacterium spp. strains. Moderate activity in the inhibition of 13 microorganisms was obtained for the four compounds 4a, 5a, 5c, and 5d.
使用简单的反应方法，高效地获得了三系列新型 8,9-二氢-7H-嘧啶并[5,4-b][1,4]二氮杂*，4a-d、5a-d 和 7a-d，产率良好。这些嘧啶并二氮杂*对 15 株分枝杆菌菌株进行了评估。四种化合物 4a、5a、5c 和 5d 对 13 种微生物的抑制活性中等。
