Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA.
Org Lett. 2012 Jul 6;14(13):3446-9. doi: 10.1021/ol301406a. Epub 2012 Jun 25.
The solid-phase synthesis of γ-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing γ-AApeptide building blocks in order to prepare γ-AApeptide sequences. This method will maximize the potential of developing chemically diverse γ-AApeptide libraries and thereby facilitate the biological applications of γ-AApeptides in the future.
报道了一种使用新型亚单体制备方法的γ-AA 肽固相合成方法，该方法利用烯丙基保护。该策略成功避免了为制备γ-AA 肽序列而制备γ-AA 肽构建块的必要性。这种方法将最大限度地发挥开发化学多样性γ-AA 肽文库的潜力，从而促进γ-AA 肽在未来的生物应用。
