Department of Prevention and Sports Medicine, Technische Universität München, Munich, Germany.
Clin Exp Dermatol. 2013 Mar;38(2):151-3. doi: 10.1111/j.1365-2230.2012.04430.x. Epub 2012 Jun 25.
Vibratory angio-oedema is a rare form of physical urticaria characterized by pruriginous weals and angio-oedema at the site of exposure to vibration. Severe treatment-resistant disease can occur, and is associated with significant disability. Therapy with omalizumab, a monoclonal IgG anti-IgE antibody, has been shown to be successful in several types of physical urticaria. We report a patient with vibratory angio-oedema for whom all standard treatments for urticaria, including omalizumab, failed to show a clinical benefit. Finally, ketotifen was tried, and unexpectedly reduced symptoms significantly. Ketotifen may thus represent a therapeutic option in patients with treatment-resistant vibratory angio-oedema.
振动性血管性水肿是一种罕见的物理性荨麻疹，其特征是在接触振动的部位出现瘙痒性风团和血管性水肿。严重的、治疗抵抗的疾病可能会发生，并与显著的残疾相关。奥马珠单抗是一种单克隆 IgG 抗 IgE 抗体，已被证明对几种类型的物理性荨麻疹有效。我们报告了一例振动性血管性水肿患者，所有标准的荨麻疹治疗方法，包括奥马珠单抗，均未显示出临床获益。最后，尝试了酮替芬，出乎意料地显著减轻了症状。因此，酮替芬可能是治疗抵抗性振动性血管性水肿患者的一种治疗选择。
