Department of Pediatrics, Washington University, St Louis, MO, USA.
J Pediatr Gastroenterol Nutr. 2012 Dec;55(6):747-50. doi: 10.1097/MPG.0b013e3182650a4d.
The aim of the present study was to investigate the relation of environmental enteropathy, as measured by the dual sugar absorption test, to linear growth faltering in 2- to 5-year-old Malawian children. Dietary quality, food insecurity, anthropometry, and site-specific sugar testing were measured in 418 children, and anthropometry was reassessed 3 months later. A linear regression model predicting linear growth was created. Better growth was associated with less urinary lactulose excretion, more clean water usage, not sleeping with animals, and no previous history of malnutrition. Eighty-seven percent of children studied demonstrated evidence of environmental enteropathy. In conclusion, abnormal gut integrity is associated with reduced linear growth in a population of rural African preschool-age children.
本研究旨在探讨通过双糖吸收试验测量的环境肠病与马拉维 2 至 5 岁儿童线性生长迟缓的关系。在 418 名儿童中测量了饮食质量、粮食不安全、人体测量学和特定部位的糖测试，并在 3 个月后重新评估了人体测量学。创建了一个预测线性生长的线性回归模型。更好的生长与更少的尿乳果糖排泄、更多的清洁水使用、不与动物一起睡觉和没有以前营养不良的历史有关。研究中 87%的儿童表现出环境肠病的证据。总之，肠道完整性异常与农村非洲学龄前儿童的线性生长减少有关。
