Sánchez Peralta A M, Oliveras-López M J, Pérez González R, Martínez Martínez F, López-García de la Serrana H
Departamento de Nutrición y Bromatología, Facultad de Farmacia, Campus Universitario de Cartuja, Universidad de Granada, Granada, España.
Nutr Hosp. 2012 Mar-Apr;27(2):456-62. doi: 10.1590/S0212-16112012000200016.
There are multiple risk factors for cancer, including obesity, sedentary lifestyle, diabetes (DM). Hormon Insulin is a growth factor that promotes cellular differentiation.
The aim of our study is to observe impaired glycaemia in cancer population compared with control.
We studied the prevalence of diabetes (DM) and impaired fasting glycaemia (IFG) in 374 patients with different types of cancer before treatment, by medical records in a Malaga hospital (Spain). We compared the prevalence of basal hyperglycaemia in these patients with general population, within an age range and by gender.
The prevalence of diabetes was 32.35% in our cancer patients. The comparison depends of age range, and by gender prevalence was: 45-54 years, DM: 40.91% in men cases, versus (vs.) 14.5% in men control (p = 0.005). 55-64 years, IFG: 23.08% in women cases, vs. 5.9% in women control (p = 0.001). 65-74 years, DM: 47.13% in men cases, vs. 25.4% in men control (p = 0.000), and IFG: 23.81% in women cases, vs. 9.5% in women control (p = 0.019). We found a higher prevalence of diabetes in specific types of cancer such as prostate (p < 0.005). Moreover, men had a higher prevalence of diabetes or less diabetes control than women in our cancer sample.
We recommend an OGTT (oral glucose tolerance test) for better diagnosis of possible DM in patients with cancer, and an appropriate treatment. It may be an independent risk factor for cancer to have decreased insulin activity, or DM.
癌症存在多种风险因素,包括肥胖、久坐不动的生活方式、糖尿病(DM)。激素胰岛素是一种促进细胞分化的生长因子。
我们研究的目的是观察癌症患者与对照组相比的血糖受损情况。
我们通过西班牙马拉加一家医院的病历,研究了374例不同类型癌症患者治疗前糖尿病(DM)和空腹血糖受损(IFG)的患病率。我们在一个年龄范围内并按性别将这些患者的基础高血糖患病率与普通人群进行了比较。
我们的癌症患者中糖尿病患病率为32.35%。比较取决于年龄范围,按性别患病率为:45 - 54岁,男性病例中DM为40.91%,男性对照组为14.5%(p = 0.005)。55 - 64岁,女性病例中IFG为23.08%,女性对照组为5.9%(p = 0.001)。65 - 74岁,男性病例中DM为47.13%,男性对照组为25.4%(p = 0.000),女性病例中IFG为23.81%,女性对照组为9.5%(p = 0.019)。我们发现特定类型癌症如前列腺癌中糖尿病患病率更高(p < 0.005)。此外,在我们的癌症样本中,男性糖尿病患病率更高或糖尿病控制情况比女性更差。
我们建议对癌症患者进行口服葡萄糖耐量试验(OGTT)以更好地诊断可能的糖尿病,并进行适当治疗。胰岛素活性降低或患有糖尿病可能是癌症的一个独立风险因素。