Department of Public Health and Primary Care, Ghent University, Corneel Heymanslaan 10, Entrance 42 - Floor 4, 9000, Ghent, Belgium.
Department of Nutrition and Dietetics, Harokopio University, 70 El Venizelou Ave, 176 71 Kallithea, Athens, Greece.
BMC Endocr Disord. 2020 Mar 12;20(Suppl 1):14. doi: 10.1186/s12902-019-0471-3.
The clinical and economic burden of type 2 diabetes mellitus on society is rising. Effective and efficient preventive measures may stop the increasing prevalence, given that type 2 diabetes mellitus is mainly a lifestyle-driven disease. The Feel4Diabetes-study aimed to tackle unhealthy lifestyle (unhealthy diet, lack of physical activity, sedentary behaviour, and excess weight) of families with a child in the first grades of elementary school. These schools were located in regions with a relatively low socio-economic status in Belgium, Bulgaria, Finland, Greece, Hungary and Spain. Special attention was paid to families with a high risk of developing type 2 diabetes mellitus.
The aim of this paper is to describe the detailed methodology of the intervention's cost-effectiveness analysis. Based on the health economic evaluation of the Toybox-study, both a decision analytic part and a Markov model have been designed to assess the long-term (time horizon of 70 year with one-year cycles) intervention's value for money. Data sources used for the calculation of health state incidences, transition probabilities between health states, health state costs, and health state utilities are listed. Intervention-related costs were collected by questionnaires and diaries, and attributed to either all families or high risk families only.
The optimal use of limited resources is pivotal. The future results of the health economic evaluation of the Feel4Diabetes-study will contribute to the efficient use of those resources.
2 型糖尿病给社会带来的临床和经济负担正在增加。鉴于 2 型糖尿病主要是一种生活方式驱动的疾病，如果采取有效且高效的预防措施，可能会阻止其发病率的上升。Feel4Diabetes 研究旨在解决有小学一年级子女的家庭的不健康生活方式（不健康饮食、缺乏身体活动、久坐行为和超重）问题。这些学校位于比利时、保加利亚、芬兰、希腊、匈牙利和西班牙社会经济地位相对较低的地区。特别关注有发生 2 型糖尿病高风险的家庭。
本文旨在详细描述干预措施成本效益分析的方法。基于 Toybox 研究的健康经济评估，设计了决策分析部分和马尔可夫模型，以评估长期（70 年的时间范围，每一年为一个周期）干预措施的性价比。列出了用于计算健康状态发生率、健康状态之间的转移概率、健康状态成本和健康状态效用的数据来源。干预相关成本通过问卷调查和日记收集，并归因于所有家庭或高风险家庭。
最佳利用有限资源至关重要。Feel4Diabetes 研究健康经济评估的未来结果将有助于这些资源的有效利用。
