携带 blaTEM-1 并赋予流感嗜血杆菌对β-内酰胺类抗生素耐药性的小质粒的分子组织。
Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae.
机构信息
Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Antimicrob Agents Chemother. 2012 Sep;56(9):4958-60. doi: 10.1128/AAC.00408-12. Epub 2012 Jun 25.
Abstract
TEM-1 is the dominant β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 carries a Tn3 resolvase gene and pA1606 and pA1209 carry an open reading frame (ORF) similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.
摘要
TEM-1 是流感嗜血杆菌中主要的β-内酰胺酶，可位于小质粒上。三种不同大小的质粒（4304 到 5646 个核苷酸）已被鉴定：pA1606、pA1209 和 pPN223。除了 TEM-1 和 Rep3 超家族的复制酶之外，pA1606 还携带 Tn3 内切酶基因，pA1606 和 pA1209 携带类似于革兰氏阳性菌中质粒重组酶基因的开放阅读框（ORF）。这些质粒转化菌株 Rd 使其具有氨苄青霉素抗性表型。
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