Foster T P, Parrott E L
Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City 52242.
J Pharm Sci. 1990 Sep;79(9):806-10. doi: 10.1002/jps.2600790913.
The release from a matrix compressed from a physical mixture of hydrogenated castor oil and ephedrine hydrochloride or procaine hydrochloride has been investigated. The effects on release of the concentration of medicinal compound, particle size of medicinal compound, agitation of dissolution medium, and porosity and tortuosity of the matrix are presented. An attempt is made to fit the experimental data to an acceptable diffusion model.
